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January 10, 2020___

Today's Rundown

Featured Story

Lilly bags late-phase Dupixent rival in $1.1B Dermira buyout

Eli Lilly has struck a $1.1 billion deal to acquire Dermira, landing it a late-phase rival to Regeneron and Sanofi’s blockbuster atopic dermatitis drug Dupixent. The takeover, which values Dermira at just a whisker above its closing price yesterday, comes months after the biotech posted phase 2b data.

Thank you to Rho for sponsoring this year's JPM 2020 coverage.

Top Stories

Aduro's staffers feel the sting, again, after Novartis walks away

It’s grim news ahead of the J.P. Morgan Healthcare Conference next week for Aduro Biotech.

Blackstone lands $3.4B life science fund, plots more fundraising

Blackstone has raised $3.4 billion for its life science fund. The financing, which could grow by another $1.2 billion, sets Blackstone up to continue placing bets such as its ventures with Novartis and Ferring. 

Ultragenyx shares jump on 'better than expected' gene therapy data

Ultragenyx Pharmaceutical saw its shares jump around 27% in trading Friday after announcing positive top-line data out of its gene therapy trial.

Roche taps Amunix's tech in $40M non-cancer R&D deal

As Amunix zeroes in on developing its own pipeline of cancer drugs, the company is licensing its platform, which lengthens the half-life of drugs, to Roche for $40 million upfront. The Swiss pharma will use it to discover and develop new drugs outside the realm of cancer.

Tyra Biosciences takes aim at treatment-resistant tumors with $50M raise

Tyra Biosciences is taking aim at treatment-resistant tumors, banking $50 million in its series A round to get on its way. The Carlsbad, California-based biotech will develop a pipeline of “very specific” small molecules to attack cancer cells that have rewired themselves to become resistant to targeted treatments.

Generation Bio grabs a $110M round to ramp up work on next-gen gene therapies

In 2018, Generation Bio broke cover with a $25 million series A, swiftly followed by a meatier $100 million second funding round.

How controlling fat 'doormen' could lead to new obesity treatments

Fat cells take in nutrients and let out energy-supplying lipids in a finely tuned process that prevents the excessive buildup of belly fat. Scientists at Yale University have discovered that the enzyme O-GlcNAc transferase helps regulate this process. In mice, depleting the enzyme caused cells to burn off lipids at a faster rate than they took in carbohydrates.

EuroBiotech Report—NorthSea B round, Boehringer deal, AstraZeneca-MiNA, Galecto and Novo

In this week's EuroBiotech Report, NorthSea raises cash for NASH trial, Boehringer buys fibrosis assets and AstraZeneca forms metabolic disease pact.

FiercePharmaAsia—Taiho, Otsuka, Chugai KRAS deals; Biocon biologics spinoff; Mark Alles' new title

A group of Japanese drugmakers have found licensees for their KRAS-focused projects. Biocon secured a private equity investment for its biologics business in preparation for an IPO. Ex-Celgene chief Mark Alles re-emerged as a board director at Chinese biotech Antengene. And more.

Chutes & Ladders—Pfizer's Read picks up position at asset manager

Pfizer ex-CEO Read picks up job at The Carlyle Group; AMAG dumps CEO Heiden; ex-Lilly chief Conterno joins team at Fibrogen.

Enrollment Showcase

Online Graduate Programs Designed for Your Career

Drexel University’s online graduate programs in biomedicine, clinical research, drug discovery, and molecular medicine were developed with working professionals in mind, providing you with the education, practical skills, and competitive edge you need to be successful in your career.  Learn more.

Resources

[Whitepaper] Digital Disruption in Biopharma: How Digital Transformation can reverse declining ROI on R&D

The beginning of this digital transformation is well underway and is likely to accelerate. Read our white paper, “Digital Disruption in Biopharma: How Digital Transformation can reverse declining ROI on R&D,” to learn more.

[Whitepaper] Telemedicine: Facilitating Clinical Trial Participation

Download this white paper and read the expert feedback that snapIoT has gathered from industry thought leaders on the evolution, evaluation, and use of telemedicine solutions in clinical trials.

[Whitepaper] Are We Transforming in the Right Way? Why Launches Can’t Be Distracted By Empty Promises.

How are your launch strategies can convert “innovation” into value for patients?

[Whitepaper] The Impact of Step-Therapy Policies on Patients

Download this complimentary paper that explores the practice of step therapy and its impact on key stakeholders in the US healthcare system.

[Whitepaper] Modernizing clinical trials with Amazon Web Services (AWS)

From IoT to data management to high-performance computing and machine learning, leading life sciences organizations are using Amazon Web Services (AWS) to develop scalable, global, predictable, and secure solutions to modernize clinical trials while mitigating risks

[Whitepaper] Why Partner with CSP’s to Validate Mission Critical Apps in the Cloud?

Why companies leverage the expertize of industry focused cloud service providers to design and build quality systems and facilitate the FDA Validation of Mission Critical Apps in the Cloud.

[Whitepaper] How to Protect your Supply Chain from Security and Compliance Threats Utilizing On-Dose Authentication Technologies

Learn more: Best practices for defending supply chain security and compliance by efficiently managing product authentication.

[Whitepaper] The Unexpected Key to Building Value in Drug Discovery and Development

Small or emerging pharmaceutical and biotech companies pursuing novel molecules and targets have two important goals: achieve clinical success and attract new rounds of funding. While there’s never a guarantee of either, certain actions can influence the outcome in your favor.

[Executive Summary] Clinical Supplies - Made to Order

Learn how recent innovations in demand-led supply and direct-to-patient distribution are converging to create a next-generation clinical supply chain that is flexible, lean and most importantly patient-centric.

[Whitepaper] Digital Twins: Creating Digital Operations Today to Deliver Business Value Tomorrow

This whitepaper highlights the challenges of implementing the right digital twin strategy while providing key use cases in the manufacturing domain for which a digital twin is extremely useful and several examples of technology trends that will shape the future.

[Q&A] Embarking Upon the Commercial Manufacturing Journey for a Biologic

In this Q&A, four Catalent Biologics experts share how scale-up, regulatory expectations, demand forecasting and process validation all play a role in the success of a biologic when embarking upon the commercial manufacturing journey.

Events