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Today's Rundown

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Johnson & Johnson's COVID-19 vaccine production lags goals as data readout nears: NYT

Amid slower than expected rollouts for the Pfizer and Moderna COVID-19 vaccines in the U.S., Johnson & Johnson’s vaccine could serve as a key boost for the nationwide immunization push. But the pharma giant has fallen behind on its initial manufacturing goals, the New York Times reports, just as its first big data readout looms.

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CureVac's new pharma partner Bayer says its COVID-19 vaccine not just an also-ran

German biotech CureVac shouldn’t be discounted from being a major COVID-19 vaccine player despite being at the tail end of the race to market.

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Pressure is building for a coordinated federal COVID-19 response. Inova Health System's CEO describes why

As pressure builds to speed vaccine distribution, Inova Health System CEO J. Stephen Jones calls for federal coordination to improve its efficiency. At some point, access to the vaccines themselves could become a limiting factor, but so far "that's not been the case," Jones said. 

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Rite Aid CEO braces for 'chaotic' few weeks as vaccine rollout expands

Rite Aid's CEO said she is bracing for a 'chaotic' few weeks in the COVID-19 vaccine rollout as a new president comes in and more people become eligible for doses.

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Will AZ's coronavirus vaccine turn a profit this year? It's 'too speculative' to predict, exec says

After AstraZeneca pledged not to profit off its COVID-19 shot during the pandemic, a report emerged that the drugmaker might be ready to call the pandemic over as soon as July. But according to EVP and biopharma president Ruud Dobber, it’s “too speculative” to predict when the vaccine may start earning money.

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Warp Speed chief Slaoui resigns at Biden's request as COVID-19 shots are unleashed: report

Operation Warp Speed co-leader Moncef Slaoui is largely credited with fostering the speedy development of Pfizer's and Moderna's mRNA vaccines against COVID-19. But the U.S. fell way short of its goal of vaccinating 20 million Americans by the end of last year, and now Slaoui has submitted his resignation to incoming President Joe Biden.

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How did Pfizer up its COVID-19 vaccine capacity? 'Out of the box manufacturing,' CEO says

Earlier this week, Pfizer partner BioNTech upped the pair’s 2021 COVID-19 output projection to 2 billion doses for 2021, up from a previous estimate of up from a previous estimate of 1.3 billion But how will the companies get there? By doing things “very differently and very out of the box in manufacturing,” CEO Albert Bourla explained Tuesday.

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Kaufman Hall: Hospital industry made 79 deals in 2020, down from 92 in 2019

A new report found that the number of deals in the hospital industry was 79 in 2020, down from the 92 that took place in 2019.

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Celltrion's COVID-19 antibody improves outcomes in phase 2

Celltrion’s anti-SARS-CoV-2 antibody has improved outcomes in patients with mild to moderate COVID-19 in a phase 2/3 clinical trial. The Korean biopharma reported lower rates of progression to severe COVID-19, shortened time to clinical recovery and reduced viral load in patients on the drug.

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A COVID-19 treatment candidate that fuses tiny antibodies from llamas and alpacas shows promise

Scientists from the University of Bonn, the Karolinska Institutet and Scripps Research Institute have designed a COVID-19 treatment by fusing "nanobodies" from a llama and an alpaca. In lab experiments, the engineered antibodies were able to neutralize emerging mutants of the novel coronavirus.

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Biopharma roundup: Sinovac's shot just 50.38% effective, Brazilian data show; J&J's vaccine manufacturing hits snag: report

J&J fell behind on its shot manufacturing goals, The New York Times reports. Sinovac's shot is just 50.38% effective, Brazil said. Researchers from a trio of institutions have synthesized nanobodies against COVID-19. Celltrion's antibody drug helped patients in a phase 2/3 trial. Plus, the world will still need CureVac's shot, a Bayer exec said.

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Healthcare roundup: Moderna, Uber partner to support uptake of COVID-19 vaccines

Follow along with the latest COVID-19 news straight from the Fierce Healthcare team.

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Imara CEO Ballal on fighting sickle cell disease during COVID-19

COVID-19 threw a wrench in Imara’s plans. The company was testing a treatment for sickle cell disease—which occurs more often in people of African descent—during a pandemic that disproportionately affected communities of color. But it learned some lessons along the way that aren’t just useful for its own work, but for anyone working on drugs for diverse populations (so really, anyone working on drugs, period).

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PPD C-suite says CROs 'better prepared' as COVID-19 surges, sees pandemic trials a long-term opportunity

Contract research organization PPD said that while the pandemic is surging again across the world, lessons since March put the industry in a better position to keep trials going, as it says approvals for new vaccines haven’t and won’t lead to a letup in its COVID-19 trial work.

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Aridis CEO Truong on why the pandemic hasn't bolstered antibiotics R&D and what needs to change

The COVID-19 pandemic has spurred enormous interest and innovation in vaccines, antivirals and anti-infective drugs and for obvious reasons. There’s another area that might have been buoyed by the threat of a new illness that had no specific treatments—but wasn’t. That area, of course, is antibiotics development.

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