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January 22, 2019

Today's Rundown

Featured Story

'In genome Editas': Bosley signs off from CRISPR pioneer

Just a few months after getting the all-clear to start its first CRISPR trial and bagging a nice check from Allergan in the process, Editas’ chief executive and president Katrine Bosley is hitting the exit.

Top Stories

FDA puts Translate Bio’s rare disease mRNA drug on hold

The FDA has placed a clinical hold on the IND for Translate Bio’s mRNA treatment for ornithine transcarbamylase deficiency, a genetic disease that causes too much ammonia to build up in the blood.

Aurinia posts mixed midphase data on would-be Restasis rival

Aurinia Pharmaceuticals has presented a mixed bag of midphase data on its challenger to Allergan’s blockbuster dry eye drug Restasis. The challenger, VOS, failed to better the tolerability of Restasis but delivered superior efficacy on secondary endpoints, suggesting it may have an unexpected edge over its rival.

Gamida Cell teams up with Be The Match to help develop its bone marrow transplant alternative

Gamida Cell is teaming up with Be The Match BioTherapies, a service-focused subsidiary of the National Marrow Donor Program, to help support the late-phase development of its cell therapy that aims to offer an alternative source of universal bone marrow transplant material for patients with blood cancers.

Sorrento shows fast, durable arthritis pain relief with ‘spicy’ injection in early study

A phase 1b study of a nonopioid, nerve-ablating painkiller from Sorrento Therapeutics showed rapid relief of osteoarthritic knee pain that lasted for nearly three months at its lowest dose, prompting the company to begin planning pivotal studies for this year.

Immunochina raises $20M for blood cancer CAR-T

Fresh from reporting clinical data at ASH, Beijing biotech Immunochina has raised $20 million in a third-round financing to speed up its CAR-T development programs.

Wren raises £18M to drug protein-misfolding diseases

Wren Therapeutics has raised £18 million ($23 million). The British biotech will use the series A round to advance its research into drugs to treat protein-misfolding diseases such as Alzheimer’s.

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