Merck KGaA lays off 100 US staffers

Today's Big News

Jan 23, 2023

Biotech may soon be defined by the 'haves and have-nots' as investors look for less risky bets


Morphic loses another Big Pharma partner as J&J follows AbbVie out of the door


Merck KGaA shrinks U.S. research team as layoffs continue to batter industry


Chasing Boehringer, Pliant sends stock soaring with midphase fibrosis data


Combo results may offer route back to approval for Agenus' unlucky cervical cancer drug 


Protein turns back clock in cartilage cells, could have therapeutic potential for osteoarthritis  


Fierce Biotech Fundraising Tracker '23: ADARx hauls in $46M in push toward the clinic; Iaso catches $74M+ for CAR-T pipeline

 

Featured

Biotech may soon be defined by the 'haves and have-nots' as investors look for less risky bets

A brutal year for biotech has private investors eyeing bets with less risk and more emphasis on single assets over drug discovery engines, but there's plenty of optimism to go around in the opening weeks of 2023. 
 

Top Stories

Morphic loses another Big Pharma partner as J&J follows AbbVie out of the door

Morphic Therapeutic has lost another Big Pharma partner. Eleven months after AbbVie walked away, Johnson & Johnson has delivered the killer blow to its own already-diminishing ties to the biotech.

Merck KGaA shrinks U.S. research team as layoffs continue to batter industry

Merck KGaA is laying off roughly 11% of its U.S. outpost, shrinking a Massachusetts R&D unit by more than 130 employees. The cuts come two months after executives revealed a push to be a leaner organization.

Enhancing Clinical Trials with More Diverse Recruitment

We initiate a discussion focused on the relation of clinical trials and the need for geographical inclusion versus societal exclusivity. With some trial sites including only 20% of the disease population in the United States, innovation is needed.

Chasing Boehringer, Pliant sends stock soaring with midphase fibrosis data

Pliant Therapeutics’ bid to upend the idiopathic pulmonary fibrosis market is gathering pace. The latest phase 2a data drop suggests dialing up the bexotegrast dose boosts efficacy without compromising safety, prompting investors to send shares in the biotech spiraling upward.

Combo results may offer route back to approval for Agenus' unlucky cervical cancer drug

Fifteen months after the FDA blindsided Agenus with a decision not to offer accelerated approval for the cervical cancer drug balstilimab, the biotech is back with fresh data for a combo featuring the therapy it claims could finally make headway.

Protein turns back clock in cartilage cells, could have therapeutic potential for osteoarthritis

Scientists have uncovered a process that drives inflammation in osteoarthritis and potentially a way to ameliorate it.

The seer: AI tool from MIT, Mass General predicts lung cancer risk in nonsmokers 6 years out

Much like its ancient Greek namesake, a new artificial intelligence tool dubbed Sybil may be able to see into the future—though its predictions are delivered to doctors rather than to mythical gods.

Fierce Biotech Fundraising Tracker '23: ADARx hauls in $46M in push toward the clinic; Iaso catches $74M+ for CAR-T pipeline

Alongside the new year, we've launched a new Fierce Biotech Fundraising Tracker to keep the pulse on the industry's financing.

With TheracosBio green light, another SGLT2 inhibitor wades into diabetes arena

Now christened Brenzavvy, bexagliflozin won a nod from the FDA to help improve glycemic control in adults with Type 2 diabetes, TheracosBio said Monday. The drug just won an approval to treat cats with diabetes about a month ago.

Dollar General pilots mobile clinics as it targets a bigger presence in healthcare

Discount retailer Dollar General is expanding into healthcare services in what could be a competitive shot across the bow for drugstores. The company is piloting mobile health clinics at three stores in Tennessee to provide customers with basic, preventive and urgent care services along with lab testing.

JPM23: Pfizer, Moderna and more look to combine COVID and flu vaccine markets

When Pfizer, BioNTech and Moderna swooped in to save the day with pandemic mRNA vaccines, few people—if any—were thinking about the long-term structure of the COVID-19 vaccine market. Now, as vaccination rates decline and government contracts dry up, that future is becoming clearer.

Health system CEO turnover rose in 2022 as more executives feel the strain from burnout

New reports outline trends among new CEO appointments and increasing pressure for those at the helm of hospitals and health systems.
 
Fierce podcasts

Don't miss an episode

'The Top Line': Panelists at Fierce's JPM Week event talk drug pricing policy, and Bayer's oncology head discusses cancer strategy

This week on "The Top Line," we take you inside Fierce's JPM Week event. Listen in on snippets from a lively panel discussion on how companies will navigate the drug pricing policies the Biden administration rolled out just last year. And hear from Christine Roth, head of Bayer's oncology strategic business unit, about the company's plans to become a strong competitor in cancer.
 

Resources

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Reduce control arm sizes by up to 35% for Alzheimer's disease

RCTs with digital twins require fewer control patients and shorten trial timelines for Alzheimer's disease.
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Quality attributes that are important for GMP-grade NTPs

What makes nucleotides suitable for current good manufacturing practices?

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Medical Affairs Metamorphosis V: The (R)evolution in Medical Communications

This paper explores how Medical Affairs is adapting medical communications to meet the demands of a new environment (part 5 in a series).
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Writing the Future of Antibody Discovery Solutions

See how high-throughput DNA synthesis combined with antibody engineering expertise provides end-to-end antibody discovery solutions.

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Scale-Up Strategies for Late-Stage Cell Therapies

Readers will learn manufacturing by Design Builds on Quality by Design, De-risking the Tech Transfer Process, and more.

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Linear Compression vs. Parallel Processing: Speeding Biologics Through Development and Into Clinical Trials

Download this paper to learn considerations on how to move a biologic through clinical trials faster, advantages of Parallel Processing, and more.

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Intranasal Drug Product Development: Formulation to Manufacturing

What are key considerations for intranasal delivery in the treatment of acute and chronic conditions?
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Clinical Supply Solutions for the Asia-Pacific Region

Learn how Catalent’s extensive network across APAC can meet a wide range of clinical supply needs for sponsors conducting trials within the region.
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Supply Services to Support Clinical Trials in Japan & Beyond

Explore Catalent’s newest clinical supply facility in Japan, including the comprehensive services & solutions it offers to help support trials both in-country & around the world.
Case Study

A Strategy to Standardize Process Characterization & Late Phase Development

Learn more on an approach for process characterization for the production of a monoclonal antibody, which will improve the efficiency and effectiveness of the process by targeting the right design and number of experiments.

 

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