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January 31, 2017

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Today's Rundown

  1. Genentech oncology head jumps ship to Bellicum as CEO

  2. Lawmakers pressure Trump on FDA hiring freeze

  3. Seres plots path back from phase 2 microbiome blowup

  4. Astellas buys rights to Auration's ruptured eardrum therapy

  5. Heptares, Cambridge Uni team up to pursue CV target

  6. Pfizer drops phase 2 diabetes drug, two earlier-stage candidates

  7. Hormone may protect ovaries from chemo damage

  8. Special Report—The top 10 drug launches of 2017

  9. Novartis, Lilly, PhRMA CEOs to face Trump and his drug-price vows at Tuesday meeting

Featured Story

Genentech oncology head jumps ship to Bellicum as CEO

As David Epstein moved from Novartis’ cancer unit to VC Flagship and Alessandro Riva also left the Swiss major for an exec role at Gilead in the last few weeks, Rick Fair has become the latest to leave a Big Pharma as he exits as head of oncology at Roche/Genentech to become the new CEO and president of Texas biotech Bellicum.


Top Stories

Lawmakers pressure Trump on FDA hiring freeze

It’s been long known that President Donald Trump wanted to enact a federal hiring freeze and allow cuts by attrition, but lawmakers have sent a letter to the White House urging Trump to come clean on what this means for the agency.

Seres plots path back from phase 2 microbiome blowup

Seres Therapeutics has plotted a path forward for its Clostridium difficile infection program after digging into the data to learn where it went wrong in phase 2. The analysis picked out suboptimal doses and misdiagnoses as potential causes of the phase 2 flop, giving Seres the encouragement to push ahead with a follow-up trial despite the weak data.

Astellas buys rights to Auration's ruptured eardrum therapy

Astellas has licensed a drug that could provide an alternative to surgery for tympanic membrane perforation (TMP)—commonly known as a ruptured eardrum—developed by California's Auration Biotech.

Heptares, Cambridge Uni team up to pursue CV target

Heptares Therapeutics has teamed up with the University of Cambridge to discover molecules that modulate a cardiovascular target. The project builds on work at Cambridge to understand the role apelin receptors play in cardiovascular conditions including ischemic heart disease and discover a selective antagonist of the target.

Pfizer drops phase 2 diabetes drug, two earlier-stage candidates

During its financials posted today, Pfizer quietly updated its pipeline showing that it has dropped three candidates from its testing programs, but as always, details were thin on the ground.

Hormone may protect ovaries from chemo damage

Chemotherapy often causes infertility in young women because the drugs are designed to damage all rapidly growing cells, including those in ovarian follicles. Now researchers from Massachusetts General Hospital believe they’ve hit upon a method for protecting ovaries from the damaging effects of chemo.

Special Report—The top 10 drug launches of 2017

After an unusually slow year for new drug approvals—the FDA greenlighted just 22 meds in 2016—it remains to be seen whether drugmakers can do much better in 2017. One thing’s for sure, though: No matter what total the industry tallies up this year, the crop will bring some would-be blockbusters and market disrupters.

Novartis, Lilly, PhRMA CEOs to face Trump and his drug-price vows at Tuesday meeting

Pharma has been called to the White House. Industry leaders will meet with President Donald Trump Tuesday morning. Eli Lilly CEO David Ricks, PhRMA chief Steven Ubl and Novartis CEO Joe Jimenez, the group's chairman-elect, are set to attend.

News of Note

Abilita Bio says it has teed up another collaboration agreement with a "major pharma partner," but is not revealing who, which will use its EMP membrane protein evolution platform. Release

Indivumed has signed a pact with Regeneron to provide it with cancer tissue samples for its research. Statement

AbCheck has hit its first clinical milestone in its antibody discovery deal with Lilly after starting enrollment for a phase 1 test. Release

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