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February 03, 2017

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Today's Rundown

  1. AstraZeneca pulls PD-L1 phase 3 combo test, RSV candidate

  2. Stemline admits it learned of—but did not disclose—patient death in cancer trial before $45M stock offering

  3. Funding sets up proof-of-concept trial for Tarveda's lead Pentarin next year

  4. Targovax climbs after posting survival data from I-O trial

  5. EuroBiotech Report: Novo’s U.K. R&D investment, Arix files for $100M IPO, AstraZeneca-Brexit, sharks and Heptares

  6. FiercePharmaAsia: FibroGen and AZ’s anemia filing in China, Astellas’ eardrum therapy buy, Takeda’s price control promise

  7. Chutes & Ladders: Genentech oncology head jumps ship

Featured Story

AstraZeneca pulls PD-L1 phase 3 combo test, RSV candidate

It’s the fourth-quarter clear out, and AstraZeneca has pulled the plug on a combo of its immuno-oncology candidate as well as axing a test of its biologic arm’s fast-tracked RSV drug as it sheds some more light on its tests in head and neck cancers.


Top Stories

Stemline admits it learned of—but did not disclose—patient death in cancer trial before $45M stock offering

Stemline Therapeutics has admitted it learnt of a death in its phase 2 cancer trial the day before it went ahead with a $45 million stock offering. The admission follows a report in The Street about the death—the third from the same side effect—that wiped more than 40% off Stemline’s stock price.

Funding sets up proof-of-concept trial for Tarveda's lead Pentarin next year

Boosted by a fresh $30 million tranche of funding, Tarveda Therapeutics will start phase 2 trials of its lead drug for advanced neuroendocrine tumors and small cell lung cancer early next year, according to CEO Drew Fromkin.

Targovax climbs after posting survival data from I-O trial

Targovax has posted two-year survival data from a phase 1/2 trial of TG01 in resected pancreatic cancer patients. More than 60% of participants were alive two years after starting treatment, sparking a 40% surge in the stock price of Targovax.

EuroBiotech Report: Novo’s U.K. R&D investment, Arix files for $100M IPO, AstraZeneca-Brexit, sharks and Heptares

In this week's EuroBiotech Report, Novo invests in U.K. R&D site, Arix files for £100 million IPO, AstraZeneca talks up Brexit opportunities and more.

FiercePharmaAsia: FibroGen and AZ’s anemia filing in China, Astellas’ eardrum therapy buy, Takeda’s price control promise

In this week's FiercePharmaAsia wrap-up, FibroGen and AstraZeneca prepare NDA in China for an anemia drug, Astellas buys rights to Auration's ruptured eardrum med, and Takeda promises to contain yearly drug price increases under 10%.

Chutes & Ladders: Genentech oncology head jumps ship

Genentech's Rick Fair leaves the company to join Bellicum as CEO, Juno Therapeutics taps Corsee Sanders as new development operations head who oversees clinical trials, and Sanofi poaches Kathleen Tregoning from Biogen as its new EVP of external affairs. Plus more hirings, firings and retirings throughout the industry.

News of Note

After a recent trial setback, Auris Medical says it has expanded its pipeline with intranasal betahistine in Meniere's disease and vestibular vertigo. Statement

Bionomics has gained a milestone bonus payment from Merck after starting a phase 1 test in Alzheimer's. Release

Axovant Sciences has taken out $55 million in a venture debt financing deal from Hercules Capital. Statement

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