Tizona on its own as Gilead walks away

Today’s Big News

Feb 7, 2024

Gilead ends blood cancer path for troubled CD47 med after increased risk of death detected


Amgen’s obesity drug takes the weight off and may keep it off too, early data suggests


Gilead will not buy Tizona after paying $300M for the right to do so


Amid GLP-1 supply constraints, Lilly to prep for oral obesity market 'at risk'


I-Mab sheds China footprint to complete transformation into US-based biotech


2 former Apple Tree investors roll toward new biotech-focused fund launching with $310M


Jazz jumps into KRAS G12D space via $10M upfront deal with regular partner Redx


Arrowhead axes assets, but spares staff, to save $100M a year in refocus on core areas

The Top Line Podcast: Don’t miss out on the newest episode. Listen now.

 

Featured

Gilead ends blood cancer path for troubled CD47 med after increased risk of death detected

Facing a full FDA clinical hold on a clutch of studies, Gilead is ending development of magrolimab in blood cancer after an “increased risk of death” was observed in a late-stage trial for the med.
 

Top Stories

Amgen's obesity drug takes the weight off and may keep it off, too, early data suggest

Amgen's obesity drug MariTide stimulates weight loss in animals and people without major side effects, new data from the company show. And unlike its competitors, it may only need to be taken once a month and perhaps not for life. 

Gilead will not buy Tizona after paying $300M for the right to do so

Gilead will not buy immunotherapy biotech Tizona Therapeutics, backing out of an option that the company paid $300 million for in 2020. 

Biotech in 2024: Opportunities, Trends & Challenges

In this exclusive interview, ICON Biotech President Chris Smyth paints a picture of the operating environment facing biotechs in 2024.

Amid GLP-1 supply constraints, Lilly to prep for oral obesity market 'at risk'

With supply strains not letting up in the growing injectable obesity med market, Lilly looks to carve out manufacturing early for its oral candidate.

I-Mab sheds China footprint to complete transformation into US-based biotech

I-Mab’s plan to become a U.S.-focused biotech took a stride forward with the news that the company is divesting its China operations.

2 former Apple Tree investors roll toward new biotech-focused fund launching with $310M

A new life science fund is emerging with over $300 million at hand and the leadership of two former investors from Apple Tree Partners. Scion Life Sciences is affiliated with healthcare private equity firm Petrichor, but the new fund is a standalone business.

Jazz jumps into KRAS G12D space via $10M upfront deal with regular partner Redx

Jazz has returned to Redx Pharma’s well, this time paying $10 million upfront for a KRAS program that includes the much-hyped G12D space.

Arrowhead axes assets, but spares staff, to save $100M a year in refocus on core areas

Arrowhead Pharmaceuticals is terminating development of a pair of pipeline prospects as part of a push to be more strategic about where it puts its dollars. With costs rising as programs enter late-stage trials, the RNA specialist plans to look “more vigorously” for partners and cull assets outside its areas of focus.

Eli Lilly’s Verzenio fails prostate cancer test as possible Novartis showdown nears

Despite reaching new heights in breast cancer, Eli Lilly’s Verzenio has been sent packing in prostate cancer. Meanwhile, the Indianapolis pharma has another phase 3 prostate cancer program in the works.

Ambience Healthcare reels in $70M for generative AI tools to battle clinician burnout

With the number of healthcare workers experiencing burnout at an all-time high, Ambience Healthcare is betting on artificial intelligence as a potential solution.

Eisai, Biogen likely to miss early launch goal for Alzheimer's drug Leqembi

While Japan’s Eisai had set the goal to reach 10,000 patients with Leqembi by the end of its 2024 fiscal year, which wraps up in March, only 2,000 patients in the U.S. were receiving the amyloid-busting antibody as of Jan. 26, Eisai explained in a third-quarter earnings presentation.

Amazon cuts hundreds of jobs in One Medical, Pharmacy units

Amazon is eliminating a "few hundred roles" across One Medical and Amazon Pharmacy, the company confirmed Tuesday.
 
Fierce podcasts

Don’t miss an episode

'The Top Line': Navigating the future of medical AI

This week on “The Top Line,” Fierce’s Conor Hale interviews Peter Shen, the North American head of digital health at Siemens Healthineers, to explore what developers and regulators can do to ensure transparency in medical AI. He also dives into how the field could potentially benefit from a 21st-century update to the Hippocratic Oath. 
 

Resources

Whitepaper

The Oncology Market – 2023 Year in Review

This paper offers a detailed review of key events and developments in the oncology market during 2023.  It’s a helpful “status report” that informs how the market is likely to evolve in 2024. It covers, vaccines, radiopharmaceuticals, ADCs, CAR-Ts, bi-specifics, & more.

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Developing and Manufacturing Drugs with HPAPIs

Discover how to effectively classify highly potent APIs and the steps required to develop containment protocols and manufacturing processes that are both safe and efficient.

 

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