BMS, Roivant sign $674M AI pact

Today’s Big News

Feb 13, 2024

Mikael Dolsten is always 'open to change' as he preps Pfizer's entry into obesity's 2nd wave


Exscientia fires CEO Andrew Hopkins over 'inappropriate' relationships with 2 employees


BMS signs $674M biobucks pact with Roivant's VantAI for molecular glues 


GLP-1 enthusiasm pushes BioAge Labs into new age with $170M series D 


Capitalizing on ADC frenzy, ProfoundBio attracts $112M oversubscribed series B


KalVista's persistence with sebetralstat pays off with Konfident phase 3 victory 


Roche dumps Repare's synthetic lethal drug days after making $40M stitch in Tapistry trial


Japan’s Ono Pharma taps Texas startup Shattack for $227M bifunctional fusion protein deal


LianBio lays off half of workforce as biotech begins to wind down


Using cancer's 'superpower' to boost T-cell therapies in mice 

The Top Line Podcast: Don’t miss out on the newest episode. Listen now.

 

Featured

Mikael Dolsten is always 'open to change' as he preps Pfizer's entry into obesity's 2nd wave

If you ask Pfizer’s chief scientist Mikael Dolsten, M.D., Ph.D., what the next pandemic will be, you may be surprised at the answer. It’s not viral or respiratory, and, in fact, it’s here now.
 

Top Stories

Exscientia fires CEO Andrew Hopkins over 'inappropriate' relationships with 2 employees

AI drug hunter Exscientia has fired CEO Andrew Hopkins effective immediately after the board determined he had engaged in two personal relationships with employees that were deemed “inappropriate and inconsistent” with company values.

BMS signs $674M biobucks pact with Roivant's VantAI for molecular glues

Bristol Myers Squibb is offering Roivant's VantAI up to $674 million biobucks in a new partnership aimed at designing molecular glues as small-molecule therapeutics.

2024 Executive Interviews at Fierce JPM Week

Fierce Life Sciences and Healthcare sit down with biotech, pharma, and healthcare executives at Fierce JPM Week.

GLP-1 enthusiasm pushes BioAge Labs into new age with $170M series D

The frenzy around GLP-1s has changed BioAge’s trajectory, as its one of a select few biotechs with a combo candidate that might enhance weight loss without muscle loss.

Capitalizing on ADC frenzy, ProfoundBio attracts $112M oversubscribed series B

With Big Pharma’s heading into 2024 with a renewed interest in antibody-drug conjugates (ADCs), it’s no surprise that ProfoundBio managed to assemble a who’s who of biotech investors for an oversubscribed series B round.

KalVista's persistence with sebetralstat pays off with Konfident phase 3 victory

KalVista's oral HAE treatment ambitions were almost dashed a year and a half ago after one midstage candidate fell by the wayside. But a sibling program has tasted victory, nailing primary and key secondary endpoints in a phase 3 trial.

Roche dumps Repare's synthetic lethal drug days after making $40M stitch in Tapistry trial

Roche has made a fast U-turn on Repare Therapeutics’ synthetic lethal drug candidate. Days after dosing a phase 2 patient and triggering a $40 million payment, Roche told the oncology biotech that it will hand back the asset following a review of its pipeline and “evolving external factors.”

Japan’s Ono Pharma taps Texas startup Shattack for $227M bifunctional fusion protein deal

Shattack Labs’ pipeline of bifunctional fusion proteins has caught the attention of Ono Pharmaceutical, with the Japanese drug developer penning a $227 million biobucks deal focused on autoimmune and inflammatory diseases.

LianBio lays off half of workforce as biotech begins to wind down

LianBio has become the latest biotech to throw in the towel, with the Chinese company announcing that a four-month strategic review has concluded there's no choice but to wind down.

Using cancer's 'superpower' to boost T-cell therapies in mice

A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study in mice suggests.

Pfizer wins pharma ad Super Bowl, beating Astellas' Veozah spot

Pfizer won the pharma ad Super Bowl. That’s the conclusion of TV outcomes company EDO, which found Pfizer saw more incremental online activity for its brand than fellow Super Bowl advertiser Astellas after they ran their ads at the big game.

Omada GLP-1 program to prioritize muscle mass restoration through expanded care track

Omada executives shared they are expanding upon its GLP-1 Care Track, pushed by the belief that helping patients regain muscle mass is a critical to weight maintenance after tapering off utilization.

In wake of Reata buyout, Biogen's key launch Skyclarys passes muster in EU

Roughly half a year after Biogen’s $7.3 billion buyout of rare disease specialist Reata Pharmaceuticals, the companies’ blockbuster bid for Reata’s Friedreich’s ataxia (FA) drug Skyclarys is starting to take shape.
 
Fierce podcasts

Don’t miss an episode

‘The Top Line’: The most anticipated drug launches of 2024

This week on “The Top Line,” we explore the most anticipated drug launches of 2024. Editor-in-Chief Ayla Ellison engages in a conversation with Fierce Pharma Marketing Senior Editor Ben Adams about the drugs likely to launch this year with the most significant sales potential by 2028.
 

Resources

Whitepaper

The Oncology Market – 2023 Year in Review

This paper offers a detailed review of key events and developments in the oncology market during 2023.  It’s a helpful “status report” that informs how the market is likely to evolve in 2024. It covers, vaccines, radiopharmaceuticals, ADCs, CAR-Ts, bi-specifics, & more.

Whitepaper

Developing and Manufacturing Drugs with HPAPIs

Discover how to effectively classify highly potent APIs and the steps required to develop containment protocols and manufacturing processes that are both safe and efficient.

 

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