Roche drugs get new lease on life at Newleos

Today’s Big News

Feb 13, 2025

Sanofi takes $250M hit after gamble on J&J E. coli vaccine ends in phase 3 failure


Amgen ends Ideaya cancer combination trial after partner unveils rival molecule


VC Longwood Fund unveils neuro biotech with $93M, assets licensed from Roche


Encoded lays off 29% of staff to fund Dravet syndrome gene therapy trial


Galapagos drops one CD19 CAR-T to focus on 'flagship' program


Aardvark heads to Nasdaq with $94M IPO to fund more appetite-suppressant trials


GSK plans to move vaccine R&D group from Maryland to the Boston area


Oligonucleotide stops gene expansion process that drives Huntington's disease: study

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Featured

Sanofi takes $250M hit after gamble on J&J E. coli vaccine ends in phase 3 failure

A year and a half after Sanofi swooped in on Johnson & Johnson’s dismantled vaccines unit to pick up an E. coli candidate, the asset has failed its phase 3 trial.
 

Top Stories

Amgen ends Ideaya cancer combination trial after partner unveils rival molecule

Amgen and Ideaya Biosciences are winding down their cancer combination study, closing off one way the Big Biotech was looking to dial up the efficacy of its PRMT5 inhibitor AMG 193.

VC Longwood Fund unveils neuro biotech with $93M, assets licensed from Roche

Newleos Therapeutics is making its debut with $93.5 million aimed at developing safer and more effective neuroscience treatments, plus several clinical programs from Roche in hand.

Encoded lays off 29% of staff to fund Dravet syndrome gene therapy trial

Encoded Therapeutics is shrinking its headcount by 29% as the gene therapy biotech draws resources away from its early-stage R&D to focus resources on its Dravet syndrome program.

Galapagos drops one CD19 CAR-T to focus on 'flagship' program

Galapagos is dropping its junior CD19 CAR-T as part of the Belgian biotech’s seemingly never-ended work to recalibrate the business.

Aardvark heads to Nasdaq with $94M IPO to fund more appetite-suppressant trials

Obesity-focused Aardvark Therapeutics is heading to the Nasdaq this morning in an IPO that matched the low end of its expectations.

GSK plans to move vaccine R&D group from Maryland to the Boston area

After calling Rockville, Maryland, home for more than eight years, GSK's vaccine and infectious disease R&D teams are planning a move northeast to Cambridge, Massachusetts.

Oligonucleotide stops gene expansion process that drives Huntington's disease: study

Less than a month after researchers unveiled that a “ticking DNA clock” is behind Huntington’s disease, scientists have now identified an antisense oligonucleotide that can slow down the disease-causing gene expansion process.

Michigan CRO buys Exploristics for its cloud-based modeling platform

Michigan-based clinical research organization MMS is boosting its data science power with a new purchase from the U.K. The firm has acquired the Northern Irish data science company Exploristics, gaining access to its cloud-based statistical modeling and simulation platform.

Pfizer outlines Talzenna's survival benefit in bid for broad prostate cancer approval

Pfizer hopes a unique life-extension benefit for its Talzenna can serve to further expand the drug's already broadest-in-class U.S. label in prostate cancer.

Hims & Hers sees 650% spike in traffic following Super Bowl ad as clash over compounded GLP-1s heats up

Hims & Hers hit the bullseye with its Super Bowl ad—it sparked a lot of attention from consumers for its brand and weight loss products. But the controversial ad also caught the attention of the pharma industry and lawmakers, who lashed the company for "deceptive" advertising.

Medicaid likely faces severe cuts in House's new budget framework

Pressure is picking up on congressional Republicans to agree on spending cuts, and all eyes are on how leadership intends to remake Medicaid.
 
Fierce podcasts

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The business case for investing in women’s health

A recent report, released at this year’s J.P. Morgan Healthcare Conference, lays out the high-growth potential of the women’s health market and its promised return on investment.
 

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The Oncology Market: 2024 Year in Review

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