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February 22, 2018

Today's Rundown

Featured Story

Gilead, Sangamo strike $3B off-the-shelf CAR-T deal

Gilead’s Kite has struck a $3 billion deal to access Sangamo Therapeutics’ zinc finger nuclease (ZFN) technology. Kite will use the ZFN gene editing platform to create next-generation, off-the-shelf CAR-T therapies to cement its position as a long-term front-runner in the growing cell therapy space.

Top Stories

Bleeding cash, Achillion to cut 20% of workforce

Months after losing its hepatitis C collaboration with Janssen, Achillion is reducing its workforce by 20% in a bid to save cash.

GW cannabinoid drug fails midphase epilepsy trial

GW Pharmaceuticals’ GWP42006 has failed to outperform placebo in a phase 2a focal seizure trial. The setback wiped 5% off GW’s stock and dented the prospects of the cannabidivarin candidate.

[Sponsored] Optimizing Humanized Model Selection for Enhanced Preclinical Immunotherapy Assessment

Tumor-bearing humanized models are vital preclinical platforms for assessing human-specific immunotherapies. Review immediately transferable humanized model strategies for accelerating immunotherapy drug discovery programs.

Gut-brain biotech Kallyope ramps up, bags $66M series B

Columbia University spinout Kallyope launched back in 2015 with $44 million and a mission: to understand how the gut communicates with the brain and discover therapeutic targets. Now, with another $66 million in the bank, the biotech plans to advance its pipeline programs and identify new candidates.

Pfizer’s John Davis splashes into biotech as Magenta CMO

John Davis, who headed early clinical development at Pfizer, joined Magenta Therapeutics as chief medical officer.

Deal-hungry Takeda forges another R&D alliance

Takeda has added another early-stage research partnership as it reboots its R&D operations, this time teaming up with two Seattle-based academic centers in a project focused on its key targets of cancer, gastrointestinal disease and neurological disorders.

Pressure is on, sponsors. AllTrials to shame delayed clinical trial results reporting

Clinical trial sponsors who fail to report study results on time to clinicaltrials.gov are now put under public scrutiny, thanks to a new online tracker devised by clinical trial transparency advocacy project AllTrials.

Regeneron vision drug Eylea sees upward tick in unexplained side-effect cases

Regeneron eye drug Eylea has been a hit on the market for years. But now, the number of patients experiencing a rare side effect is climbing, and doctors don’t know why.

Resources

[Whitepaper] Medical Device Innovation: Are You Outrunning The Competition?

The competitive landscape in medical device R&D is tough. And simply investing in R&D is no guarantee for profitability. So how do you accelerate time-to-market?

[Whitepaper] How Life Sciences Companies Use Box for Regulated Content in the Cloud

Learn how biopharma and medical device companies can now collaborate on, manage and distribute regulated clinical, lab and manufacturing content in Box. That means all of your content is standardized on a single content repository that meets regulatory and compliance standards, so you can eliminate inefficient silos, enable seamless collaboration and accelerate the validation process.

[Whitepaper] CFO's, Is This Part Of Your Corporate TO DO List?

Employee stock option trading & administration, Restricted stock transactions (Rule 144), Affiliated trading plans (10b5-1), Directed share plans, Equity comp plan administration — private to public

[Whitepaper] Choosing the Right Solution: Improving the Site Feasibility Process

Selecting the right sites to conduct your clinical trials will determine the success or failure of meeting your enrollment goals.

[Whitepaper] How Do Sponsors Ensure Quality in Global Clinical Trials?

Global clinical trials are the trend and gaining in popularity, but running a global trial is not a straightforward process. This white paper explores some of the challenges associated with global clinical trials and considerations for ensuring that the collected data comply with the trial's overall objectives.

[Webinar] Validating a 7 Day Membrane Filtration Sterility Test using Celsis®

Join us as we discuss how Charles River Celsis® helped Labor L+S AG validate a 7-day membrane filtration sterility test using existing protocols.

[Infographic] Evolution of Flexible Commercial Biologics Manufacturing

Learn how Catalent Biologics is paving the way for flexible biologics development and manufacturing through advanced technologies and fully integrated multi-product facility.

[eBook] Developing Site-specifically Modified ADCs: Using a Chemoenzymatic Approach

Download the eBook to get articles from various Elsevier journals highlighting developments in ADC technology.

[Article] Optimizing titer and use of a specific enzyme for generating a fully processed antibody

Learn how cell development and process scale-up can be optimized for antibodies requiring additional processing.

[Webinar] Within-Subject Clinical Trials: Intro to New Methods & Stat. Models

In this webinar, we will introduce the rapidly-evolving within-subject clinical trial (WSCT) methods for early phase evidence generation that require fewer people, less time, and usually less funding than traditional early phase methods.

Events

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