Lilly's FXR buy sends Organovo stock up 244%

Today’s Big News

Feb 26, 2025

Eikon remains in megaround mode with $350M series D to fund cancer trials


AstraZeneca, eyeing $5B peak sales, reports phase 3 breast cancer win for oral SERD


Eli Lilly buys Organovo's FXR program for $10M, sending biotech's stock skyrocketing 244%


Harbour offshoot pens $395M biobucks deal for preclinical rival to Neurocrine's Crenessity


Alopexx seeks $11M IPO to advance ex-Sanofi infectious disease drug


With no buyer for Tryvio, Idorsia claws back $100M from a double-asset deal with Viatris


House budget plan advances, paving way for major Medicaid cuts  

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Featured

Eikon remains in megaround mode with $350M series D to fund cancer trials

Eikon Therapeutics is no stranger to eye-catching funding rounds, and the cancer-focused biotech has continued this trend with a $350.7 million series D to fuel its various clinical trials.
 

Top Stories

AstraZeneca, eyeing $5B peak sales, reports phase 3 breast cancer win for oral SERD

AstraZeneca has advanced its push to make camizestrant a blockbuster, reporting a phase 3 win for the oral SERD at an interim analysis. The trial hit on progression-free survival, its primary endpoint, but is yet to show patients live longer on the drug candidate.

Eli Lilly buys Organovo's FXR program for $10M, sending biotech's stock skyrocketing 244%

Eli Lilly has acquired Organovo’s lead asset, a clinical FXR agonist designed to treat inflammatory bowel disease, in a deal worth up to $50 million in biobucks. Since the buy was announced, Organovo’s stock has skyrocketed 244%.

5 Market Access Mistakes That Can Derail Your EU Orphan Drug Launch

Avoid common pitfalls in EU orphan drug market access—learn how local expertise can help navigate pricing, reimbursement, and regulatory hurdles.

Harbour offshoot pens $395M biobucks deal for preclinical rival to Neurocrine's Crenessity

The deal will see HBM Alpha Therapeutics, which was formed around Harbour’s antibody expertise, transfer the global rights outside of China for a corticotropin-releasing hormone therapy to an unnamed “business partner.”

Fortrea's Alaric Jackson Talks AI in Clinical Trials

Fortrea's CTO discusses AI's expanding role in clinical trials, from discovery to execution, and its potential to improve patient outcomes and diversity.

Alopexx seeks $11M IPO to advance ex-Sanofi infectious disease drug

Alopexx is forging ahead with long-gestating plans to go public, updating IPO paperwork to fund trials of candidates including an infectious disease antibody that was once the focus of a $375 million deal with Sanofi.

With no buyer for Tryvio, Idorsia claws back $100M from a double-asset deal with Viatris

With the latest hopes of licensing its hypertension drug Tryvio falling through, Idorsia has moved to claw back $100 million in upcoming development costs from a separate licensing deal with Viatris.

House budget plan advances, paving way for major Medicaid cuts

Republican holdouts, who stated repeatedly they would not vote for the bill, ultimately opted to advance legislation which will require significant Medicaid cuts.

With $27B plan to build 4 new plants, Eli Lilly doubles down on US drug manufacturing

At a press conference in Washington, D.C. dubbed “Lilly in America,” the Indianapolis drugmaker said it will begin construction on four new production facilities in the U.S. The effort will more than double what the company has earmarked for domestic drug manufacturing since 2020, bringing the total outlay to more than $50 billion.
 
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What were the biggest clinical trial flops of 2024?

This week on "The Top Line," we dive into several of the biggest failures in clinical-stage drug development last year and discuss what the biopharma industry can learn from these setbacks.
 

Resources

Whitepaper

The Oncology Market: 2024 Year in Review

This paper reviews key developments in the oncology market during 2024 and outlines what they mean for the future.

 

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