Praxis flouts futility finding in ph. 3 tremor trial

Today’s Big News

Feb 28, 2025

Eli Lilly feels Magnet's pull with molecular glue deal potentially worth $1.65B


BridgeBio's KRAS-focused cancer spinout backs SPAC as path to Nasdaq


Praxis flouts phase 3 futility finding, forging ahead with tremor trial despite interim setback


Mission changes, shuttering lab to focus on clinical assets


Nxera sells APAC license to lupus drug to Viatris for $10M upfront


Chutes & Ladders—Private equity firms take over bluebird's nest


Research reveals ‘ticking DNA clock’ behind Huntington’s disease


Fired HHS civil servants, veterans fear for the future of US healthcare

The Top Line Podcast: Don’t miss out on the newest episode. Listen now.

 

Featured

Eli Lilly feels Magnet's pull with molecular glue deal potentially worth $1.65B

The molecular glue wave that first began years ago is still swelling, with Eli Lilly earmarking approximately $1.65 billion to develop new versions of the sticky molecules in collaboration with Magnet Biomedicine.
 

Top Stories

BridgeBio's KRAS-focused cancer spinout backs SPAC as path to Nasdaq

For a while, special purpose acquisition companies were biotech’s hot ticket to the public markets. While interest in this path has died down in recent years, BridgeBio’s former cancer unit thinks it could work for them.

Praxis flouts phase 3 futility finding, forging ahead with tremor trial despite interim setback

Praxis Precision Medicines has been blindsided by a recommendation to stop a phase 3 essential tremor trial. Two months after Praxis CEO Marcio Souza said the chances of the trial being futile were “less than 3%,” the biotech has learnt the study looks unlikely to meet its primary endpoint at an interim analysis.

5 Market Access Mistakes That Can Derail Your EU Orphan Drug Launch

Avoid common pitfalls in EU orphan drug market access—learn how local expertise can help navigate pricing, reimbursement, and regulatory hurdles.

Mission changes, shuttering lab to focus on clinical assets

AbbVie-partnered Mission Therapeutics is tweaking its trajectory, closing a preclinical laboratory in the U.K. to focus on its two clinical candidates.

Fortrea's Alaric Jackson Talks AI in Clinical Trials

Fortrea's CTO discusses AI's expanding role in clinical trials, from discovery to execution, and its potential to improve patient outcomes and diversity.

Nxera sells APAC license to lupus drug to Viatris for $10M upfront

Nxera Pharma has sold the Asia-Pacific rights to its phase 3 autoimmune drug to Viatris for $10 million upfront.

Chutes & Ladders—Private equity firms take over bluebird's nest

Gene therapy maker bluebird bio’s 15-year flight has landed in the nest of private equity firms Carlyle and SK Capital in a buyout that went for $3 per share. Mirati and Ipsen’s former CEO David Meek, who currently chairs Sobi, will take the reins at bluebird upon the deal’s close, which is expected to be in the first half of this year.

Research reveals ‘ticking DNA clock’ behind Huntington’s disease

This week on "The Top Line," we hear from Steven McCarroll, Ph.D., whose research team at the Broad Institute of MIT and Harvard recently uncovered new insights into the cause of Huntington's disease.

Fired HHS civil servants, veterans fear for the future of US healthcare

The Trump administration is moving urgently to remake health departments in its vision. Federal workers worry the actions will impair the nation’s healthcare system in countless ways,

If GSK thrives in '25, CEO Emma Walmsley's pay could more than double to $27M

For GSK CEO Emma Walmsley, there was good news and bad news in the company’s annual report. While it revealed that she took a 16% pay cut in 2024, it also laid out a new compensation plan which could make her one of the highest-paid chief executives in the industry this year.

Private equity buyout could lead to Walgreens breakup: reports

A rumored private equity buyout of Walgreens could lead the company to be split up, according to media reports.

Fierce Pharma Asia—Eisai's US restructuring; China investigates former NMPA official; Pfizer-Summit collab

Eisai plans to lay off 121 employees in the U.S. A former deputy director of China's drug agency is under investigation by anti-corruption authorities. Pfizer has formed a clinical trial collaboration with Akeso's partner Summit Therapeutics. And more.
 
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Research reveals ‘ticking DNA clock’ behind Huntington’s disease

This week on "The Top Line," we hear from Steven McCarroll, Ph.D., whose research team at the Broad Institute of MIT and Harvard recently uncovered new insights into the cause of Huntington's disease.
 

Resources

Whitepaper

The Oncology Market: 2024 Year in Review

This paper reviews key developments in the oncology market during 2024 and outlines what they mean for the future.

 

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