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Top StoriesMerck's Keytruda, up for new FDA nod, spurs lengthy responses in small cell lung cancerMonday, April 1, 2019 Merck & Co. is awaiting an FDA decision for Keytruda in previously treated small cell lung cancer, and it has new numbers to boost its case. Almost one-fifth of patients in a pooled analysis responded to the PD-1 inhibitor, and those who did saw prolonged benefits. Chi-Med, AstraZeneca's savolitinib helps some Tagrisso-resistant EGFR lung cancer patientsSunday, March 31, 2019 AstraZeneca’s Tagrisso has taken the EGFR lung cancer market by storm, but some patients develop resistance to the therapy. Enter Chi-Med and its MET inhibitor, savolitinib. Apexigen, BMS steal the show with promising I-O combo in pancreatic cancerMonday, April 1, 2019 California biotech Apexigen said during the annual AACR meeting that a combination of its CD40-activating antibody with Bristol-Myers Squibb’s PD-1 inhibitor Opdivo and chemotherapy shrunk tumors in 20 out of 24 patients with pancreatic cancer. Astellas pads Xospata's AML lead with chemo-beating survival dataMonday, April 1, 2019 Astellas is looking to snap up share with Xospata before a head-to-head rival hits the acute myeloid leukemia scene, and some new survival data could help speed that process along. One year after mammoth lung cancer win, Merck's Keytruda holds its own in tough-to-treat subgroupsMonday, April 1, 2019 At last year’s AACR annual meeting, Merck’s Keytruda-chemo combo stole the spotlight with stellar lung cancer data. And this year, the company was back to show the regimen's results held up in historically tough-to-treat patient groups. TG Therapeutics' umbralisib shrinks tumors in 52% of lymphoma patientsMonday, April 1, 2019 TG Therapeutics’ PI3K delta inhibitor, umbralisib, put up encouraging phase 2b data in marginal zone lymphoma, shrinking tumors in more than half of the patients followed long enough to be evaluated. Of these patients, nearly one-fifth were in complete remission, that is, their cancer was undetectable after treatment. Bristol-Myers Squibb's Opdivo-Yervoy duo provokes response in rare tumorsSunday, March 31, 2019 Bristol-Myers Squibb has found success with its Opdivo-Yervoy combo in treating various common tumors. But it turns out the duo can help some patients with rare tumors, too. Vaccine prevents cancer in mouse models of Lynch syndromeMonday, April 1, 2019 People with the genetic disorder Lynch syndrome face a more than 70% lifetime risk of developing colorectal cancer, as well as an elevated risk of other cancers. In preclinical studies, a vaccine developed at Weill Cornell lowered cancer risk. The researchers are now planning trials in people.
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