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April 05, 2019

Today's Rundown

Featured Story

Merrimack 0 for 3 as it dumps cancer drug over safety fears, axes staffers (again)

Merrimack is dumping another cancer therapy after a recent trial flagged adverse event worries, leading the biotech to swing the ax across its already severely depleted workforce as it gives up on its third and final clinical shot on goal.

Top Stories

AstraZeneca, Merck, Myriad move to test BRACAnalysis in prostate cancer

After attesting to its use in ovarian, breast and pancreatic cancers, the trio of AstraZeneca, Merck & Co. and Myriad Genetics is now bringing the latter’s companion diagnostic to bear on metastatic castration-resistant prostate cancer. The BRACAnalysis CDx test will be used to hunt for BRCA mutations in men eligible for the Big Pharmas’ PARP-inhibiting Lynparza therapy.

NeuroServo's portable EEG could become a better way to detect delirium

Montreal-based NeuroServo is working on an EEG device that could become an objective test for delirium, replacing standardized but subjective questionnaires that are the current standard for diagnosing the condition.

[Sponsored] Biotech Companies Explore Alternative Strategies to Fund Growth

Deloitte discusses how biotech companies are exploring alternative strategies to fund growth including IPOs, collaborative arrangements, and share-based payment arrangements.

EuroBiotech Report—U.K. startups boost, AgomAb funding, Novartis' IFM deal and Galapagos' success

In this week's EuroBiotech Report, Cambridge Innovation Capital committed nearly $200 million to biotechs, agnostic mAb maker AgomAb got off a healthy series A, Novartis penned a potential $1.6 billion biobucks pact with IFM and Galapagos reported positive data for JAK inhibitor filgotinib.

FiercePharmaAsia—Daiichi’s new CEO and $6.9B AZ deal; Keytruda China market debate

Daiichi Sankyo nabbed a $6.9 billion antibody drug conjugate deal with AstraZeneca as it appointed a new CEO; Keytruda became the first PD-1/L1 to land a Chinese nod in untreated non-small cell lung cancer; Chi-Med rolled out positive data for MET inhibitor savolitinib; and more.

Chutes & Ladders—Soon-Shiong sued over 'catch-and-kill' of potential Abraxane rival

Soon-Shiong sued over "catch-and-kill" of potential Abraxane rival drug; Gottlieb reflects on his tenure before joining the club of ex-FDA chiefs; and British biotech Artios nabs Eli Lilly, AstraZeneca R&D veteran. Those moves plus more hirings, firings and retirings throughout the industry.

Resources

[Webinar] Doing Trials in Russia? Disrupt the market barriers through eClinical

How to cut a study budget by 4 times? How to process CRFs 3 times faster? What made a CRO switch from a US vendor to Data MATRIX? In 45 minutes, we will dissolve myths about entering the market.

[Whitepaper] Key Life Sciences Trends, 2019 and Beyond

The year’s biggest compliance and technology trends in life sciences. Learn about the latest trends impacting the biotech, medical device and pharmaceutical industries.

[Whitepaper] The New World of Allosteric Modulation: Another Shot on Goal

Learn how to utilize allosteric modulation to maximize its full potential in drug discovery programs. Download this white paper to learn more.

[Whitepaper] Advanced HDX-MS and Native-MS for Improved Biologic Candidate Selection and Development

Discussion of the potential for improving biologic drug development success through earlier, strategic application of advanced mass spectrometry, because currently, with most biologic drugs, including gene therapies, failures are realized in late-stage development, after substantial investment has been made in a candidate.

[Whitepaper] Workbench for Biomarker and Translational Research

Clinical trials and biomarker data from patients when unified, harmonized, and made searchable; is a rich, reliable and controlled resource for research. This paper sets out the requirements for a Translational and Biomarker Research Workbench for scientists using the experiences from use of Xbiom™ at BioPharma.

[Whitepaper] Meet Our Uncle: 12 Protein Stability Applications on One Platform

Download this whitepaper to learn more!

[Whitepaper] Flow Chemistry For Modern API Development & Manufacturing

Is Flow Chemistry right for your API Development?

[Whitepaper] Systolic Heart Failure: Real-World Study Using Electronic Health Records

Real-World case study by Veradigm suggests that new medications specifically approved for the treatment of systolic heart failure may be underutilized despite being important advances in patient care.

[Article] Are you ready for 2008 Microsoft SQL and Windows Servers end of life?

Software end of life puts you at risk for data breaches, business disruption and liability. Support for Microsoft SQL Server 2008/2008 R2 and Windows Server 2008/2008 R2 ends on July 9, 2019 and January 14, 2020, respectively. Learn how you can turn these risks into a strategic business advantage.

[Whitepaper] Better Market Intelligence With Smart Search

From new regulations to drug pricing and the latest M&A deals, learn how AI is making it easier for competitive intelligence to uncover the insights they need to stay ahead of the curve.

[Case Study] TriCore Reference Laboratories Transforms to Clinical Lab 2.0 Model

Analytics using patients’ real-time longitudinal laboratory results, and claims data, yielded higher value information and new revenue streams for TriCore reference laboratories.

[Whitepaper] Accelerating Clinical Trials through Access to Real-World Patient Data

Whitepaper on leveraging normalized real-world patient data to streamline clinical trials, reduce delays and lower costs.

[eBook] 2018 Weekly Compendium

The Biopharma industry is moving at lightning speed and it can be a challenge to keep pace. Here at Biotech Primer we spend hours each week researching, writing, and editing original content for the Biotech Primer WEEKLY with one goal in mind: to help everyone better understand the latest science and technology driving today’s healthcare industry.

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