| Today's Big NewsApr 7, 2023 |
| By Nick Paul Taylor Genentech has published the findings of its investigation into an alleged fraud and a cover-up involving a 2009 Nature paper co-authored by Marc Tessier-Lavigne. None of the 35 current and former employees interviewed for the probe reported knowing of fraud, but the process did leave unanswered questions. |
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By Gabrielle Masson Takeda is moving away from early R&D work in the AAV gene therapy and rare hematology spaces, with an unknown number of employees set to “transition out” of the pharma. |
By Annalee Armstrong A cell has to know what it is to do its job. New research from Trinity College Dublin has helped reveal just how cells establish their identities, which could have implications for developing more targeted cancer treatments. |
By Max Bayer,Gabrielle Masson Amarin CEO abruptly resigned after investor activists shook up the board. CinCor's former CEO jumps to Abivax after AstraZeneca sale. Page joins Arvinas to lead global oncology strategy. |
By Fraiser Kansteiner At the behest of an independent data monitoring committee, Merck and Eisai have called it quits on their phase 3 study of Keytruda plus Lenvima as an initial treatment in unresectable or metastatic melanoma. |
By Angus Liu AbbVie and J&J are pulling two Imbruvica accelerated approvals after failing to satisfy the FDA. They're doing so even though the drug met its primary endpoint in a confirmatory trial in one of the indications. |
By Conor Hale A group of investors says the company’s leadership has shown slow progress in clinical trials and presided over sliding stock value. |
By Kevin Dunleavy Four months after filing for bankruptcy, Clovis Oncology has found a buyer for its assets including the rights to ovarian cancer drug Rubraca. Pharma& Schweiz GmbH of Switzerland submitted the highest bid at an auction on March 30. The agreement is for $70 million up front, with an additional $50 million on achieving regulatory milestones and $15 million in sales-related milestones. |
By Zoey Becker After a long battle, it's officially the end of the road for Covis' preterm birth med Makena. The FDA finally revoked its approval after two advisory committee recommendations to do so. |
By Zoey Becker In yet another TAF/TDF drug lawsuit for Gilead Sciences, the company faces claims from two plaintiffs that it caused injuries with its older tenofovir products while shelving a safer generation of new products. |
By Robert King New bipartisan legislation in the House aims to tie Medicare physician payments to rises in inflation to better keep pace with rising costs. |
By Teresa Carey This week on "The Top Line," we discuss how this year is chock-full of blockbuster drugs headed for the patent cliff, besides the well-known patent cliff for AbbVie's Humira. We also cover Johnson & Johnson's talc settlement offer and more of this week's top headlines. |
By Angus Liu BioNTech linked up with a Chinese company on two antibody-drug conjugates. Sanofi is reportedly looking to separate its consumer health unit in India through a de-merger. Takeda is doubling down on celiac disease with yet another deal in the area. And more. |
Fierce podcasts Don't miss an episode |
| This week on "The Top Line," we discuss how this year is chock-full of blockbuster drugs headed for the patent cliff, besides the well-known patent cliff for AbbVie's Humira. We also cover Johnson & Johnson's talc settlement offer and more of this week's top headlines. |
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| May 1-3, 2023 | Jersey City, NJ |
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