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April 19, 2019

Today's Rundown

Featured Story

Lilly, Pfizer's phase 3 pain data show mixed efficacy, clear safety issues

A phase 3 trial has painted a mixed picture of the safety and efficacy of Eli Lilly and Pfizer’s painkiller tanezumab. Neither dose of the nerve growth factor inhibitor hit all the co-primary efficacy goals, and both fared worse than placebo on the safety assessments.

Top Stories

Mustang flying high as 'bubble boy' gene therapy aces small study

They’re using the “c” word. Mustang Bio’s stock leapt more than 400% in after-hours trading Wednesday on the news that a gene therapy it licensed from St. Jude Children’s Research Hospital cured eight infants with “bubble boy” syndrome.

BI and Lilly's diabetes drug Jardiance reverses heart failure in animal models

Mount Sinai researchers showed that in a pig model of heart failure, the diabetes drug Jardiance improved heart function. After two months of treatment, the animals experienced reductions in pulmonary congestion and biomarkers of heart failure.

[Sponsored] Mitotech: a Dry Eye treatment aimed at mitochondria

Mitotech – a biotech specializing in targeting mitochondria – is moving into late stage of clinical development in Dry Eye Disease.

IBM to wind down Watson's work in AI-based drug discovery: report

IBM is ending sales of its Watson programs aimed at artificial intelligence-based drug discovery and development due to poor financial returns, according to a report from Stat.

EuroBiotech Report—GSK cuts, Genfit at the FDA, Kiadis buys CytoSen, Cerevance hire and Acticor

In this week's EuroBiotech Report, GSK plans R&D cuts, Genfit gets breakthrough status and Kiadis pens deal to buy CytoSen.   

FiercePharmaAsia—Indian generics contenders; Chi-Med's HK listing; Qilu Pharma explosion

A group of Indian generics makers is starting to take the lead in U.S. generics prescriptions; Chi-Med has filed to list on the Hong Kong Stock Exchange; an explosion at a Qilu Pharma subsidiary killed 10 workers and injured 12.

Chutes & Ladders—Gilman buckles in as Arrakis raises $75M, while Wotton takes over at Obsidian

Gilman buckles in as Arrakis raises $75 million, while Wotton takes over at Obsidian; ex-GSK immunology chief to lead Kintai Therapeutics; and Insys swaps CEOs as Subsys marketing crackdown continues. Those moves plus more hirings, firings and retirings throughout the industry.

Resources

[Whitepaper] Personalized Test for Treatment Prediction in Depression

Total Brain Announces Personalized Test for Treatment Prediction in Depression with 80% Accuracy.

[Whitepaper] Observed Impact of Medication Price Transparency on Patients and Practices

Prescription price transparency technology is here – but is it making a difference? Find out HERE.

[Whitepaper] Redefining Your Value to Win Empowered Patients: Six Steps to Success

Every life sciences firm talks about patient-centricity, but are you doing what it takes to deliver?

[Whitepaper] Key Life Sciences Trends, 2019 and Beyond

The year’s biggest compliance and technology trends in life sciences. Learn about the latest trends impacting the biotech, medical device and pharmaceutical industries.

[Whitepaper] The New World of Allosteric Modulation: Another Shot on Goal

Learn how to utilize allosteric modulation to maximize its full potential in drug discovery programs. Download this white paper to learn more.

[Whitepaper] Advanced HDX-MS and Native-MS for Improved Biologic Candidate Selection and Development

Discussion of the potential for improving biologic drug development success through earlier, strategic application of advanced mass spectrometry, because currently, with most biologic drugs, including gene therapies, failures are realized in late-stage development, after substantial investment has been made in a candidate.

[Whitepaper] Workbench for Biomarker and Translational Research

Clinical trials and biomarker data from patients when unified, harmonized, and made searchable; is a rich, reliable and controlled resource for research. This paper sets out the requirements for a Translational and Biomarker Research Workbench for scientists using the experiences from use of Xbiom™ at BioPharma.

[Whitepaper] Meet Our Uncle: 12 Protein Stability Applications on One Platform

Download this whitepaper to learn more!

[Whitepaper] Flow Chemistry For Modern API Development & Manufacturing

Is Flow Chemistry right for your API Development?

[Whitepaper] Systolic Heart Failure: Real-World Study Using Electronic Health Records

Real-World case study by Veradigm suggests that new medications specifically approved for the treatment of systolic heart failure may be underutilized despite being important advances in patient care.

[Article] Are you ready for 2008 Microsoft SQL and Windows Servers end of life?

Software end of life puts you at risk for data breaches, business disruption and liability. Support for Microsoft SQL Server 2008/2008 R2 and Windows Server 2008/2008 R2 ends on July 9, 2019 and January 14, 2020, respectively. Learn how you can turn these risks into a strategic business advantage.

[Whitepaper] Better Market Intelligence With Smart Search

From new regulations to drug pricing and the latest M&A deals, learn how AI is making it easier for competitive intelligence to uncover the insights they need to stay ahead of the curve.

[eBook] 2018 Weekly Compendium

The Biopharma industry is moving at lightning speed and it can be a challenge to keep pace. Here at Biotech Primer we spend hours each week researching, writing, and editing original content for the Biotech Primer WEEKLY with one goal in mind: to help everyone better understand the latest science and technology driving today’s healthcare industry.

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