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April 26, 2019

Today's Rundown

Featured Story

AstraZeneca dumps Amgen-partnered drug after midphase fail

AstraZeneca has dropped Amgen-partnered autoimmune drug prezalumab from its pipeline. The action follows the failure of the anti-B7RP1 antibody in a midphase Sjöogren’s syndrome trial.

Top Stories

ReNeuron climbs on updated vision loss cell therapy data

ReNeuron has reported further improvements in the vision of patients treated with its cell therapy. The mean increase in visual acuity across the three retinitis pigmentosa patients now stands at 23 letters, well above the level deemed clinically meaningful by the FDA.

Celgene wraps up EU, U.S. filings for anemia drug luspatercept

Three weeks after filing luspatercept for FDA approval, Celgene has submitted the anemia drug for consideration by the European Medicines Agency. The applications come four months after the Acceleron-partnered drug reduced the reliance of beta-thalassemia patients on blood transfusions in a phase 3 trial.

[Sponsored] Using the Innate Immune System to Treat Disease

Reprogramming the innate immune system, rather than the adaptive immune system, may be the path to treat both cancer and Alzheimer’s disease.

New insight into melatonin could lead to better sleep drugs

Melatonin is a hormone that regulates our biological clock, but scientists don’t fully understand how it interacts with two cellular receptors to do the job. Now, a team of researchers has shed some light on the receptors’ structures, which they say could help improve the design of drugs to treat sleep disorders.

EuroBiotech Report—Genentech backs U.K. accelerator, GSK punts heart drug, Boehringer and more

In this week's EuroBiotech Report, Genentech backs U.K. startup accelerator, GSK punts failed heart drug and more. 

FiercePharmaAsia—Lilly China asset sale; Daiichi's bispecific I-O deal; Torrent 1M-bottle sartan recall

Eli Lilly sells legacy brands and a manufacturing facility in China to focus on new therapies. Daiichi Sankyo picks its first bispecific antibody developed under a deal with Zymeworks. Torrent Pharma recalls more than 1 million bottles of losartan. And more.

Chutes & Ladders—Novartis nabs GSK executive for Sandoz CEO

Novartis nabs GSK executive for Sandoz CEO, bringing in some digital prowess; Pfizer oncology executive hops to Aduro as CMO; and Alkermes' former COO will head up operations at Paragon. Those moves plus more hirings, firings and retirings throughout the industry.

Resources

[Whitepaper] Personalized Test for Treatment Prediction in Depression

Total Brain Announces Personalized Test for Treatment Prediction in Depression with 80% Accuracy.

[Whitepaper] Observed Impact of Medication Price Transparency on Patients and Practices

Prescription price transparency technology is here – but is it making a difference? Find out HERE.

[Whitepaper] Redefining Your Value to Win Empowered Patients: Six Steps to Success

Every life sciences firm talks about patient-centricity, but are you doing what it takes to deliver?

[Whitepaper] Key Life Sciences Trends, 2019 and Beyond

The year’s biggest compliance and technology trends in life sciences. Learn about the latest trends impacting the biotech, medical device and pharmaceutical industries.

[Whitepaper] The New World of Allosteric Modulation: Another Shot on Goal

Learn how to utilize allosteric modulation to maximize its full potential in drug discovery programs. Download this white paper to learn more.

[Whitepaper] Advanced HDX-MS and Native-MS for Improved Biologic Candidate Selection and Development

Discussion of the potential for improving biologic drug development success through earlier, strategic application of advanced mass spectrometry, because currently, with most biologic drugs, including gene therapies, failures are realized in late-stage development, after substantial investment has been made in a candidate.

[Whitepaper] Workbench for Biomarker and Translational Research

Clinical trials and biomarker data from patients when unified, harmonized, and made searchable; is a rich, reliable and controlled resource for research. This paper sets out the requirements for a Translational and Biomarker Research Workbench for scientists using the experiences from use of Xbiom™ at BioPharma.

[Whitepaper] Meet Our Uncle: 12 Protein Stability Applications on One Platform

Download this whitepaper to learn more!

[Whitepaper] Flow Chemistry For Modern API Development & Manufacturing

Is Flow Chemistry right for your API Development?

[Whitepaper] Systolic Heart Failure: Real-World Study Using Electronic Health Records

Real-World case study by Veradigm suggests that new medications specifically approved for the treatment of systolic heart failure may be underutilized despite being important advances in patient care.

[Article] Are you ready for 2008 Microsoft SQL and Windows Servers end of life?

Software end of life puts you at risk for data breaches, business disruption and liability. Support for Microsoft SQL Server 2008/2008 R2 and Windows Server 2008/2008 R2 ends on July 9, 2019 and January 14, 2020, respectively. Learn how you can turn these risks into a strategic business advantage.

[Whitepaper] Better Market Intelligence With Smart Search

From new regulations to drug pricing and the latest M&A deals, learn how AI is making it easier for competitive intelligence to uncover the insights they need to stay ahead of the curve.

[eBook] 2018 Weekly Compendium

The Biopharma industry is moving at lightning speed and it can be a challenge to keep pace. Here at Biotech Primer we spend hours each week researching, writing, and editing original content for the Biotech Primer WEEKLY with one goal in mind: to help everyone better understand the latest science and technology driving today’s healthcare industry.

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