Zolgensma-type gene therapy for dementia
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Today's Rundown

Catalent Trending Topic: Cell & Gene Therapy
Read on to understand how the industry is addressing gene therapy and cell therapy research and development.

Featured Story

Spying synthetic lethal promise, Pfizer bets $25M on Zentalis, will support cancer trials

Pfizer is throwing its weight behind Zentalis Pharmaceuticals’ synthetic lethality candidate, making a $25 million investment in its new partner and agreeing to jointly advance the prospect through the clinic.

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Top Stories

UPDATE: Amgen opts to DARP-out after seeing early data from $550M Molecular Partners biobucks collab

After a peak at the earliest data for Molecular Partners’ DARPin therapy, Amgen is saying thanks but no thanks on the $550 million partnership. The company's Novartis-partnered COVID-19 therapy is also delayed.

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Zolgensma for dementia? AviadoBio gains orphan tag for one-dose gene therapy

Move over, Zolgensma. A new one-dose therapy that could provide a similar mode of treatment for the red-hot therapy area of neurodegenerative disorders has received orphan designation from regulators on both sides of the Atlantic.

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Sponsored: Using Knowledge Graphs to Drive Drug Discovery

Biomedical knowledge graphs can power many different application in drug discovery. Learn which key feature you should look for and why.

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After phase 2 flop, BerGenBio posts new data on COVID-19 prospect

The effort to establish bemcentinib as a COVID-19 drug continues. Eleven months after failing a phase 2 trial, the Danish biotech has shared data from a second, smaller trial that linked the drug to significant changes.

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Future shaky at Solid Bio as it shaves off 35% of workforce, chief operating officer plans exit

Things are anything but stable at Solid Biosciences, a life sciences company targeting therapies for Duchenne muscular dystrophy, as it plans to cut over a third of its workforce—for the second time in two years—and Chief Operating Officer Joel Schneider, Ph.D., departs.

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BridgeBio strategy head departs amid company’s second round of layoffs this year

BridgeBio is cutting staff for the second time this year as the company continues to reel from a phase 3 defeat in December. At the same time, the company's chief strategy officer is headed for the exit.

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2 become 1: Caladrius and Cend merge into tumor-focused Lisata Therapeutics

Not an acquisition but a “merger of equals.” That’s how Caladrius Biosciences and Cend Therapeutics have described their transformation into the newly christened Lisata Therapeutics.

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Cytovia inks SPAC merger to get natural killer cells prospects into the clinic

Cytovia Therapeutics has found an $ISLE to dock at in the choppy waters of biotech public markets. The natural killer (NK) cell startup is set to merge with a SPAC to secure the cash to enter the clinic and try to get through to a data drop in 2024.

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Novartis spotlights BeiGene-partnered cancer immunotherapy data to move it earlier in the treatment paradigm

Less than two weeks after BeiGene won approval in China for tislelizumab in esophageal cancer, its Western partner, Novartis, is announcing data that it hopes will lead to endorsements for the PD-1 checkpoint inhibitor in the U.S. and Europe.

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Symeres buys Organix to enter lipids market and grow in the US

European drug discovery services firm Symeres has acquired U.S. lipid maker and organic chemistry contractor Organix.

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Here's what CEOs at the US' top for-profit health systems earned in 2021

A fresh flock of health system CEOs took home millions in salary, stock awards and other remuneration during Year Two of the COVID-19 pandemic.

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Intel lends its deep learning AI to DiA Imaging’s heart ultrasound analysis tech

Artificial intelligence developer DiA Imaging Analysis has a fever, and the only prescription is more AI.

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Sygnature Discovery buys Peak Proteins to bolster drug discovery business

Preclinical contractor Sygnature Discovery has bought Peak Proteins, a chemistry services provider set up by ex-AstraZeneca protein biochemistry and structural biology scientists.

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Centene's Michael Neidorff was the highest-paid payer CEO last year. Take a look at what other execs earned

The CEOs at six major national insurers earned nearly $115 million combined in total compensation last year.

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Resources

Research: Healthcare Has No Borders: The Role of Rescue Sites in Times of Global Calamity

More than 570 clinical trials in Ukraine have been disrupted. Unanticipated disruptions to medical testing and clinical trials impede progress toward new breakthroughs and new therapies that millions of patients around the world hang their hope on. What role do rescue sites play?

Infographic: United Cargo: Providing Comprehensive Solutions For the Most Critical Shipments

The United Cargo team has made a commitment to pharmaceutical and medical partners that we are equipped to support their vaccine transportation needs safely and effectively across our expansive global and domestic network. The safety and security of these commodities is our priority, and we are proud to be a trusted partner in these efforts. Download infographic now.

Research: Get Access to AdisInsight A Year In Review

The journey of drug development in 2021 delivered to your inbox: top 10 AdisInsight drug profiles viewed, new drug profiles released, overview of drug launches, key deals, research trends in 2021 and much more (free of charge).

Whitepaper: Oncology Market Outlook: Key Trends to Watch

What’s in store for the oncology market in 2022 and beyond? This paper looks at 5 trends driving the market.

Whitepaper: Uncovering the hidden value of quality in chemical supply

Learn how to position quality as a central component within your raw material sourcing strategies for the chemicals used throughout your workflows. Download the free whitepaper from Thermo Fisher Scientific.

Events