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May 11, 2018

Welcome to FierceLifeSci Weekly Digest, your roundup of the biggest and most popular stories from each of our publications.

Featured Story

UPDATED: Novartis says it got nothing from a $1.2M consulting deal with Trump's lawyer

After a scandal erupted Tuesday when Stormy Daniels' lawyer claimed Novartis made "suspicious financial transactions" to President Donald Trump's personal lawyer, the drugmaker offered up its own version of events. Novartis admitted its payments totaled $1.2 million—$100,000 a month—to Michael Cohen for consulting, even though it determined after one meeting that Cohen couldn't offer any help.

Top Stories Of The Week

Johnson & Johnson preps for esketamine filing in resistant depression, despite a missed trial

A new type of drug for depression has been a long time coming, and Johnson & Johnson is looking increasingly likely to end the drought with esketamine—even though one of its late-stage trials missed the mark.

Takeda to vault into Big Pharma with $62B Shire buyout—and megamerger cuts are on the way

Shire and Takeda have finally, officially, agreed on a deal. The Japanese drugmaker will shell out $62 billion on the rare disease specialist, almost half of that in cash. Now, it'll be up to Takeda to make the buyout pay, and it's eyeing $1.4 billion in cost cuts—including some 3,600 jobs—to help do that.

Genentech forms $1B discovery collaboration with soil-prospector Lodo Therapeutics

Genentech signed up for a broad, open-ended drug discovery collaboration with Lodo Therapeutics that could be worth nearly $1 billion, focused on deriving unique, natural products from the microbial DNA found in soil.

Portola's Andexxa bleeding antidote wins FDA nod but will see limited release

Portola has finally overcome FDA concerns to win approval of its coagulation factor Xa, a bleeding antidote for some of the new generation blood thinners like Xarelto and Eliquis. Portola will launch Andexxa next month, although initial supplies will be limited by a manufacturing changeover required by the FDA.

Turning CRISPR from a gene-editing hatchet to a ‘word processor’

Even though CRISPR offers the promise of cutting out disease-causing genes, it can also make unintentional edits to healthy DNA. A new gene-editing tool is designed to act more like the search-and-replace function in word processing, precisely cutting out genetic variants, then helping DNA repair itself to lessen off-target effects.

Who do you trust? For doctors, it's Bristol-Myers Squibb and Biogen

For the first time, DRG Digital’s Manhattan Research queried doctors about which pharma companies they trust in its annual Taking the Pulse survey. They asked a range of questions about those that have quality content, empathy for healthcare providers and a patients-first motivation. However, credible scientific content and nonpromotional value adds from pharma showed the strongest correlation to trust.

Where is Pfizer putting its R&D hopes? Vaccines are front and center

On Pfizer’s first-quarter earnings call, CEO Ian Read drew up a long list of R&D programs the company’s expecting to drive future growth. But when Bernstein analyst Tim Anderson asked him to narrow it down, Read mentioned vaccines first.

Hologic makes $732M write-down as recent $1.6B Cynosure deal hits turbulence

Hologic’s move into medical aesthetics isn’t going according to plan. The diagnostics player bought its way into the sector with the $1.6 billion takeover of Cynosure in March 2016 but was forced to write down the value of the acquired business by $732 million this week.

Pfizer launches new collaboration with XtalPi for AI drug modeling

Pfizer plans to expand its work with Chinese tech startup XtalPi to develop an AI-powered platform to model small-molecule drugs as part of its discovery and development efforts.

Resources

[Whitepaper] A Simpler Approach to RBM in Clinical Trial Management

Learn how cloud-enabled solutions provide real-time insights and actionable analytics to improve clinical trial safety and performance in this short presentation.

[Whitepaper] Five Tracking Spreadsheets it’s Time for Regulatory to Retire

Find out how to eliminate regulatory’s tracking spreadsheets for good.

[Whitepaper] Regulatory Transformation at UCB

UCB took a more holistic approach to managing regulatory processes. Read how their efforts are paying off.

[Whitepaper] Risk-based Approach to Change Management of GxP Systems

Learn how to reduce change management burden, keep systems current, and maintain compliance by applying a risk-based approach to change management of GxP systems.

[Whitepaper] MSL Outlook: What is the Future of Field Medical Affairs?

Learn how leading companies, from the world’s top pharma to emerging biotechs, are empowering their medical affairs teams.

[Whitepaper] Leveraging Scientific Insights for Better Healthcare Engagement

To deliver value to key opinion leaders, medical affairs needs to tailor their engagement with deeper analytics and insights.

[Whitepaper] The Future of Life Sciences Events Management

Explore a new model for events management, and learn how to deliver more value.

[Whitepaper] Digitizing the Global Life Sciences Supply Chain: The Critical Role of Digital Transaction Management

Life science companies are experiencing a significant transformation in how they bring new products to market.

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