Tango ditches med after liver tox

Today’s Big News

May 23, 2024

Investors say ‘no bueno’ as Cytokinetics stymies M&A prospects with complex Royalty deal


Takeda gets crafty with $1.2B biobucks deal to create molecular glues with Degron


Tango drops USP1 inhibitor over liver toxicity in patients during phase 1 trial


Palisade's ulcerative colitis drug prevents symptoms in mice, is nontoxic in dogs


AstraZeneca pays $19M to Harbour BioMed's Nona for preclinical cancer antibodies


Cancer trial sites are growing, but poor performance is, too: report

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Featured

Investors say 'no bueno' as Cytokinetics stymies M&A prospects with complex Royalty deal

Cytokinetics has now all but assured that a buyout is nowhere in the near future with a $575 million Royalty Pharma funding deal that drew the ire of investors.
 

Top Stories

Takeda gets crafty with $1.2B biobucks deal to create molecular glues with Degron

Takeda has taken a trip all the way to Shanghai to find just the right kind of glue to stick together a $1.2 billion biobucks deal for new candidates in oncology, neuroscience and inflammation.

Tango drops USP1 inhibitor over liver toxicity in patients during phase 1 trial

Tango Therapeutics has discarded one of its cancer drugs on the dancefloor after the USP1 inhibitor was linked to reports of liver toxicity in a phase 1 trial.

Palisade's ulcerative colitis drug prevents symptoms in mice, is nontoxic in dogs

Palisade Bio’s PDE4 inhibitor to treat the inflammatory bowel disease ulcerative colitis appears to be effective in mice and doesn't cause toxicity in dogs, study findings presented at the annual Digestive Disease Week conference.

AstraZeneca pays $19M to Harbour BioMed's Nona for preclinical cancer antibodies

Days after AstraZeneca set out how new oncology drugs would help fuel its “bold” ambition to almost double its revenue by the end of the decade, the Big Pharma has further swelled this pipeline via a deal with Harbour BioMed subsidiary Nona Biosciences.

Cancer trial sites are growing, but poor performance is, too: report

Clinical trial sites for cancer are proliferating, but a lack of investigators with experience in trial recruitment is weighing on their performance, according to a report released May 23 by trial analytics company Phesi.

Pfizer, busy with $4B savings drive, plots even more cuts out to 2027

Pfizer has made frequent headlines in recent months as it moves forward with a campaign to save $4 billion in annual costs by the end of this year. Now, the company has unveiled another savings drive that will run longer.

Roche and Abu Dhabi government to collect data on rare spinal diseases

Roche and the government of Abu Dhabi have set up a new public-private partnership to study spinal muscular atrophy and Duchenne muscular dystrophy in the Middle East. 

Home COVID testmaker Cue Health to shut down operations, lay off staff: report

According to a report from the San Diego Union-Tribune, the company will shutter operations at the end of this week, while laying off its remaining staff and leadership.

Wyden pushes for CMS to crack down on broker misbehavior

A key senator is calling on the Centers for Medicare & Medicaid Services to crack down on brokers who submit fraudulent enrollments for Affordable Care Act plans.

MilliporeSigma boosts its gene therapy manufacturing capability with $600M acquisition of Mirus Bio

MilliporeSigma, the Massachusetts-based contract manufacturing arm of Merck KGaA, is increasing its presence in the gene therapy manufacturing field as it has signed an agreement to acquire Mirus Bio for $600 million. The Wisconsin-based company develops and commercializes transfection reagents, which allow genetic material to be incorporated into cells.
 
Fierce podcasts

Don’t miss an episode

'The Top Line': From cell collection to commercial contracting: Advancements in cell & gene therapy manufacturing (Part II)

This week’s episode of “The Top Line” is the second part of a three-part series exploring the latest advancements in cell and gene therapy manufacturing.

 

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Branded Digital Companions in Biopharma

This paper defines “digital companions” in biopharma, explores their value from the patient & company perspectives, & outlines a process for successfully fielding a new digital companion.
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Designing Patient-Centered Endpoint in Rare Disease Trials

To make every rare disease trial count, we design patient-centric, relevant strategies for sponsors and caregivers to produce impactful results every time.
 

Industry Events

On Helix

Date: ‌4 ‌July ‌2024 ‌- ‌Location: ‌Babraham ‌Research ‌Campus, ‌Cambridge ‌UK