June 05, 2017

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Today's Rundown

  1. J&J's Zytiga slashes death risk by 38% in earlier-stage prostate cancer patients

  2. AstraZeneca's Lynparza, now in hot PARP battle, posts 42% survival win in breast cancer

  3. ASCO data show 'deepening response' to Incyte's epacadostat/Keytruda combo

  4. ASCO dark horse Nanjing Legend Biotech shines with promising CAR-T data

  5. Pfizer's two-time loser dacomitinib finally wins in phase 3 against AstraZeneca's Iressa

  6. Roche's Alecensa trounces Pfizer's Xalkori in head-to-head ALK matchup—again

  7. How much does Perjeta add to Herceptin postsurgery? Depends how you slice it

  8. Bristol-Myers Squibb's Opdivo, Yervoy put the brakes on mesothelioma in phase 2

  9. Prepping for FDA filing, Loxo rolls up data on its site-agnostic cancer med larotrectinib

  10. Eisai's Lenvima nabs survival edge in liver cancer showdown with Bayer's Nexavar

  11. Celltrion biosim, eyeing Herceptin's megasales, measures up to the Roche med in phase 3

Featured Story

J&J's Zytiga slashes death risk by 38% in earlier-stage prostate cancer patients

Johnson & Johnson may soon be able to move prostate cancer med Zytiga into an earlier disease stage, thanks to game-changing new data that rolled out Saturday at ASCO.

Top Stories

AstraZeneca's Lynparza, now in hot PARP battle, posts 42% survival win in breast cancer

Back in February, AstraZeneca announced that its Lynparza had become the first PARP inhibitor to find success outside of ovarian cancer, posting positive results among breast cancer patients. And Sunday, the British drugmaker revealed just how positive those results were.

ASCO data show 'deepening response' to Incyte's epacadostat/Keytruda combo

Analysts say the data back up the potential of using the two immuno-oncology drugs in combination, with improving response rates and good tolerability, at least in some cancers.

ASCO dark horse Nanjing Legend Biotech shines with promising CAR-T data

Chinese firm Nanjing Legend Biotech grabbed much attention at ASCO, showing that its CAR-T candidate could be a safe and effective way to treat relapsed or refractory multiple myeloma.

Pfizer's two-time loser dacomitinib finally wins in phase 3 against AstraZeneca's Iressa

Pfizer’s EGFR lung cancer candidate, dacomitinib, doesn’t have a pretty past. But the New York drugmaker has finally rung up a phase 3 victory.

Roche's Alecensa trounces Pfizer's Xalkori in head-to-head ALK matchup—again

Novartis’ Zykadia just won the right to challenge Pfizer’s Xalkori for the first-line ALK-positive lung-cancer crown. But the way Roche sees it, that crown is Alecensa’s for the taking, as soon as it can nab an FDA approval, too.

How much does Perjeta add to Herceptin postsurgery? Depends how you slice it

Since March, when Roche announced that adding Perjeta to blockbuster Herceptin staved off postsurgery breast cancer progression in early-stage patients, the question has been “By how much?” As it turns out, the answer is, “Not a lot.”

Bristol-Myers Squibb's Opdivo, Yervoy put the brakes on mesothelioma in phase 2

New data suggest immunotherapy could stall mesothelioma progression—and that when it comes to Bristol-Myers Squibb’s checkpoint inhibitors, two might be better than one.

Prepping for FDA filing, Loxo rolls up data on its site-agnostic cancer med larotrectinib

CHICAGO—When Merck & Co.’s Keytruda won approval last week to treat tumors based on a biomarker rather than location in the body, it was hailed as a big step for precision medicine. Hoping to be part of that journey, Loxo Oncology unveiled new larotrectinib data at ASCO Saturday.

Eisai's Lenvima nabs survival edge in liver cancer showdown with Bayer's Nexavar

Bayer and its stalwart Nexavar have had the first-line liver cancer field to themselves for years. But Eisai is doing its best to change that.

Celltrion biosim, eyeing Herceptin's megasales, measures up to the Roche med in phase 3

Chasing biosim partners Mylan and Biocon for one of the top targets in the pharma industry, Celltrion reported Sunday that its version of Roche’s breast cancer med Herceptin stacked up to the reference blockbuster in a late-stage trial.

News of Note

Philips inked two precision medicine deals concurrent with ASCO, a research deal with Memorial Sloan Kettering Cancer Center and a project with Illumina and Navican to widen access to precision medicine. FierceMedTech story

IBM, which markets its Watson supercomputer to improve cancer treatment, unveiled three studies showing Watson agreed with doctors on a treatment course up to 96% of the time. FierceMedTech story

Among all the many promos for oncology therapies at ASCO, only one campaign highlighted a class of drugs that hasn’t received FDA approval yet. FiercePharmaMarketing story

Resources

[Webinar] Get on Track with Serialization: Lessons Learned

As the pharmaceutical industry races to meet the DSCSA November 2017 deadline, challenges and complexities of serialization are becoming clear.  Join Alcami to discuss lessons learned, mistakes to avoid and gain insight on how to achieve compliance.

[Whitepaper] Make Your Clinical Trials a Success

Gain critical insights into how to design and implement pragmatic trials and generate relevant, high-level real-world evidence. Learn when to conduct PTs, design considerations, ethical regulatory issues — and more.

[Webinar] Leveraging Medical Insights for Better Healthcare Engagement

Join this global webinar to learn a new approach for demonstrating medical affairs' impact with better metrics - beyond reach and frequency, enabling launch success and better engagement with strategic KOL insights, and increasing your organization's share of voice in the healthcare landscape.

[Marketplace] Halo Pharmaceuticals: See us at CPhl North America Booth 3132

Agile. Flexible. Collaborative. Proven. That’s Halo Pharma – making contract clinical development and commercial manufacturing go smoothly.

[Whitepaper] Addressing Immunotherapy Drug Development Challenges: An Evidence-Based Approach

Discover how you can successfully mitigate risks and maximize trial success by creating a comprehensive strategy that plans for the difference in immunotherapy development and proactively monitors execution.

[Whitepaper] The Paperless Future of Healthcare and Life Sciences

DocuSign’s eSignature solutions modernize healthcare and life science organizations by eliminating paper and antiquated signature processes while meeting compliance requirements and reducing costs and errors.

[Whitepaper] DocuSign Life Sciences eBook: Reducing Cycle Time with Digital Transaction Management

The patients who rely on your scientific leadership are expecting more.

[Whitepaper] Streamline Regulatory Compliance in Life Sciences with Digital Transaction Management

The U.S. Department of Justice has collected upwards of $17 billion in settlements from the healthcare industry since 2009, including more than $2 billion from a single life sciences company.

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