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June 21, 2019

Welcome to FierceLifeSci Weekly Digest, your roundup of the biggest and most popular stories from each of our publications.

Featured Story

Allergan, following years of turmoil and resistance, heads for split: analyst

Allergan's share prices have significantly fallen from their high in 2015, but now the company is ready to make a big move in response to its struggles, one analyst writes.

Top Stories Of The Week

Special Report—The top 20 drugs by 2018 U.S. sales

Using corporate financial statements and annual earnings transcripts, FiercePharma has put together its list of the top 20 drugs by 2018 U.S. sales.

Sanofi quits Voyager gene therapy deal once worth up to $845M

Sanofi is quitting two more programs it picked up in a 2015 pact with Voyager—a gene therapy for Huntington’s disease and one for Friedreich’s ataxia.

Sanofi to ax 466 jobs, step up focus on cancer, gene therapy R&D 

Sanofi is cutting 466 jobs in France and Germany as part of the reorganization of its R&D group. The job losses are part of a pivot away from cardiovascular diseases and toward immuno-oncology drugs and gene therapies.

Merck scouts replacements for CEO Frazier less than a year after scrapping retirement rule: report

It was less than a year ago that Merck’s board scrapped a policy requiring CEOs to retire at the age of 65 in a move designed to keep Ken Frazier around. Now, the company is scouting replacements for the long-tenured helmsman, reports say.

After losing its CMO to the FDA, Roche's Flatiron Health nabs biopharma veteran

After its nearly $2 billion buyout by oncology giant Roche last winter, Flatiron has hired a new chief medical officer as it looks to push on under its new parent in the world of electronic health records and real-world data.

Bluebird Bio delays Zynteglo launch as manufacturing trips up another gene therapy

Bluebird Bio, which this month got conditional European approval for its first gene therapy, says the launch will not occur until 2020 because regulators required it to "tighten up" its manufacturing before treating its first commercial patient.

Reviving tired T cells to improve immuno-oncology treatments

A University of Pennsylvania team has discovered a protein that helps determine the fate of exhausted T cells—and that might be able to be targeted to improve immuno-oncology treatments.

GSK snares top pharma honors at Lions Health with first Grand Prix in years

CANNES, FRANCE—GlaxoSmithKline and its agency McCann Health broke the dry spell for pharma winners at Lions Health, picking up the first Grand Prix since 2016. The winning entry? A smartphone app that measures lung capacity, released in China.

Editor’s Choice—Celgene hands PD-1 tislelizumab med back to BeiGene, forfeiting $150M

Barely two years after forking over $263 million up front for the ex-Asia rights to BeiGene’s PD-1 drug, Celgene is bowing out—and paying a $150 million termination fee to do it.

Editor’s Choice—Sanofi EVP's Bioverativ blabbing ends in insider trading cases

For Sanofi, snapping up Biogen spinout Bioverativ for $11.6 billion bolstered its rare disease franchise. But for a Swiss man, an early whiff of the deal has allegedly brought some illegal gains—and now, a civil and a criminal case in the U.S. Who's the Sanofi EVP who may have tipped him off?

Resources

[Whitepaper] Satisfying GxP Requirements Using the Internet of Things (IoT)

How can the Internet of Things (IoT) enable you to meet GxP?

[Whitepaper] Managing Comorbidities in Type 2 Diabetes – Real World Evidence for Change

Patients living with diabetes deserve better – Real-World Evidence for effecting/realizing change in the management of type 2 diabetes and cardiovascular/renal comorbidities.

[Whitepaper] Agile Competitive Intelligence Strategies For Healthcare

What is agile competitive intelligence, and how can it help take market research to the next level?

[POCKET GUIDE] Reference and Literature Management Made Easy

Get 5 quick tips for faster research and better results!

[Report] Precision medicine from concept to clinic

In this publication, Blue Latitude Health maps the journey of stakeholders impacted by the rise of precision medicine today. Download the report.

[Whitepaper] Flow Chemistry: A Scale-Up Solution for Modern API Development & Manufacturing

Increase Safety & Flexibility with Flow Chemistry

[On-Demand Webinar] Lessons Learned Implementing an End-to-End RIM Solution

IONIS shares best practices for implementing an end-to-end RIM solution in this on-demand webinar. Watch now.

[Whitepaper] Site-specific, Patient-centered and Whip-smart: Enrollment Assistants Adapt to a Shifting Landscape

Increasingly complex clinical trials place a tremendous burden on study sites, exacerbating already-troubling recruitment and enrollment issues. Overwhelmed, many sites may not be up to the task or have the appropriate infrastructure, creating costly delays that keep new therapies from patients.

[Case Study] Clinical Supply Management

Download the case study to learn about the clinical supply management tools that helped a small sized pharma company during phase III of a multi-arm oncology study.

[Video] Demand Led Services and Clinical Supply Efficiency

Watch a short video on demand led supply model. It is designed to meet the needs of patients, clinical sites, clinical team and sponsors and results in shorter lead time, less waste, less stock out risk and no booklet labels.

[eBook] Strategies for Efficient Clinical Supply Management and Forecasting

Download the eBook to explore a proactive approach for clinical supply management.