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June 28, 2019

Welcome to FierceLifeSci Weekly Digest, your roundup of the biggest and most popular stories from each of our publications. Also,FierceLifeSci will not publish next Friday, July 5, in observance of Independence Day, but we'll be back in your inbox the following week.

Featured Story

AbbVie, nearing the end of Humira's historic run, scoops up a struggling Allergan for $63B

Allergan investors have been pushing for action from its management amid struggles, and AbbVie has been hunting for new revenue streams. Now, the companies are set to combine.

Top Stories Of The Week

Special Report—The top 10 drug launches of 2019

Cancer is probably the most sought-after indication in the biopharma world, but it’s missing from the 2019 class of top drug launches. Instead, treatments in immunology and rare genetic diseases have grabbed the limelight.

Editor’s Choice—Analysts rip into AbbVie, Allergan's $63B deal, citing culture clash, strategy concerns and more

AbbVie made a major splash Tuesday with its proposed $63 billion buyout of Allergan that’ll create a top-5 pharma giant. But analysts and investors were hardly impressed.

From prison, Shkreli sues—and settles with—Retrophin executives

Martin Shkreli settled a lawsuit he filed against his former Retrophin colleagues, claiming they “unceremoniously and illegally” ousted him in 2014. He had sought more than $30 million in damages.

Celgene, say goodbye to Otezla: BMS agrees to sell psoriasis drug to clear $74B merger

The feds found a solution to fears that Bristol-Myers Squibb and Celgene would corner the psoriasis market: You can have your merger, but you don’t get to keep Celgene blockbuster Otezla.

Sanofi, Regeneron asthma prospect struggles against Dupixent

A phase 2 asthma trial of Sanofi and Regeneron’s REGN3500 has met its primary endpoint. But the IL-33 antibody performed numerically worse than Dupixent and showed little promise in combination with the approved drug.

Editor’s Choice—FDA nixes Daiichi's blood cancer drug quizartinib after Japanese regulators wave it through

Just three days after Daiichi Sankyo’s Xospata challenger scored approval in Japan for a form of acute myeloid leukemia, the FDA has declined to clear the drug in the U.S. The snub comes after a series of troubles for quizartinib.

Pharma's got its chief digital officers. Now let's see results: Sanofi exec

Sanofi’s newly appointed chief digital officer, Ameet Nathwani, M.D., isn’t surprised to see CDOs proliferating across Big Pharma. But he does think he and his counterparts have some work to do if they want to stick around.

Could inhibiting both HDAC and PD-1 improve immuno-oncology treatments?

Adding OnKure’s HDAC-inhibiting drug, OKI-179, overcame resistance to anti-PD-1 therapy in mouse models of B-cell lymphoma, a University of Colorado team found.

Novartis sells Colorado site to maker of CBD products

A manufacturing facility that Novartis discarded because of declining generics sales is getting a new life. The plant near Boulder, Colorado, will be converted to produce CBD products from hemp by a company riding that wave.

3D printing lungs using blue light, hydrogel and 'yellow dye #5'

They say you are what you eat, but some scientists may be taking that maxim a step further. To build the complex vascular channels around 3D-printed lungs, the researchers used a liquid hydrogel solution that solidifies when exposed to blue light.

Resources

[Whitepaper] Satisfying GxP Requirements Using the Internet of Things (IoT)

How can the Internet of Things (IoT) enable you to meet GxP?

[Whitepaper] Managing Comorbidities in Type 2 Diabetes – Real World Evidence for Change

Patients living with diabetes deserve better – Real-World Evidence for effecting/realizing change in the management of type 2 diabetes and cardiovascular/renal comorbidities.

[Whitepaper] Agile Competitive Intelligence Strategies For Healthcare

What is agile competitive intelligence, and how can it help take market research to the next level?

[POCKET GUIDE] Reference and Literature Management Made Easy

Get 5 quick tips for faster research and better results!

[Report] Precision medicine from concept to clinic

In this publication, Blue Latitude Health maps the journey of stakeholders impacted by the rise of precision medicine today. Download the report.

[Whitepaper] Flow Chemistry: A Scale-Up Solution for Modern API Development & Manufacturing

Increase Safety & Flexibility with Flow Chemistry

[On-Demand Webinar] Lessons Learned Implementing an End-to-End RIM Solution

IONIS shares best practices for implementing an end-to-end RIM solution in this on-demand webinar. Watch now.

[Whitepaper] Site-specific, Patient-centered and Whip-smart: Enrollment Assistants Adapt to a Shifting Landscape

Increasingly complex clinical trials place a tremendous burden on study sites, exacerbating already-troubling recruitment and enrollment issues. Overwhelmed, many sites may not be up to the task or have the appropriate infrastructure, creating costly delays that keep new therapies from patients.

[Case Study] Clinical Supply Management

Download the case study to learn about the clinical supply management tools that helped a small sized pharma company during phase III of a multi-arm oncology study.

[Video] Demand Led Services and Clinical Supply Efficiency

Watch a short video on demand led supply model. It is designed to meet the needs of patients, clinical sites, clinical team and sponsors and results in shorter lead time, less waste, less stock out risk and no booklet labels.

[eBook] Strategies for Efficient Clinical Supply Management and Forecasting

Download the eBook to explore a proactive approach for clinical supply management.