New Alzheimer’s target in star-shaped brain cells
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Today's Rundown

Catalent Trending Topic: Cell & Gene Therapy
Read on to understand how the industry is addressing gene therapy and cell therapy research and development.

Featured Story

Vaccine combo hits back at treatment-resistant cancer in fight backed by US Department of Defense

New research shows a one-two hit from an experimental vaccine combo is significantly more effective at fighting off treatment-resistant cancers in animal models than either approach by itself—and the Department Defense is throwing down money to move the science into the clinic.  

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Top Stories

Manipulating T-cell fate to improve CAR-T therapy in solid tumors

Inhibiting a protein could boost the efficacy of CAR-T cells by letting newly activated T cells preferentially differentiate toward long-lasting memory T cells rather than the short-living effector cells, scientists at St. Jude Children’s Research Hospital have shown.

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Researchers look to the stars for new Alzheimer's target

To help crack Alzheimer's disease, researchers are looking to a North Star—or, more accurately, a star-shaped cell in the brain that could play a role in progression of the neurodegenerative disease. 

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Enzyme inhibitor could counter bad 'seeds' that let leukemia bounce back

Leukemia is notorious for being very aggressive and hard to eradicate from the body. The culprits are leukemic stem cells—known as “seed” cells—that drive resistance to chemotherapy and can trigger a relapse of the cancer.

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'The Top Line' podcast: Why we need an Alzheimer's moonshot, a controversial take on diversity in biotech, plus this week's headlines

This week on "The Top Line," we discuss why scientists say we need an Alzheimer's moonshot. We also talk about a controversial take on diversity during a panel at the BIO conference. Plus, we'll hear award-winning ads that tug at our heartstrings.

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COVID-19 tracker: Omicron variant could cause global surge, WHO says; J&J recipients opt for other boosters

A new COVID-19 variant, the omicron variant, could soon surge, the World Health Organization said. Those who received the Johnson & Johnson vaccine are often opting for other vaccines as a booster. Plus more.

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The 15 highest paid biopharma CEOs of 2021

In a year in which biopharma revenues increased dramatically, especially among companies that brought COVID-19 products to the market, many firms laid out eye-popping pay packages for their chief executives. Bookending this year's list are longtime CEOs who retired from powerhouse U.S. companies during the year—No. 1 Alex Gorsky of Johnson & Johnson and No. 15 Ken Frazier of Merck.

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Resources

eBook: 12 Pitfalls in Europe

For an emerging biopharma company, Europe can be very attractive. But it can also be complex and confusing. This e-book covers the 12 most common pitfalls for companies entering European markets for the first time, offering guidance to help growing companies avoid them and succeed.

Whitepaper: The Most Suitable Dosage Form Technologies for the Oral Delivery of Lipid-Based Formulations

What is the most suitable dosage form technology for the Oral Delivery of Lipid-Based Formulations?

Whitepaper: Medical Affairs Metamorphosis II: Medical Affairs’ Evolving Role as Insight Generator

Medical Affairs plays a critical role in generating insights to inform strategic decisions, but that role is changing. This paper explores why, and how MA teams can stay ahead of the curve.

Article: Formulation Strategies When Transitioning From Vial to PFS

Learn how formulation development for a PFS affects manufacturing to drive the industry toward optimizing delivery of injectable products and, ultimately, improving patient care.

eBook: Streamline HCP interactions management

Don’t miss these critical considerations when evaluating your HCP interactions management program.

White Paper: Jump Start for Biotech: New Lab Startup Guide

Sponsored by Thermo Fisher Scientific The journey for starting or expanding a lab can be exhilarating, while also being challenging--learn how this free program provides savings and solutions to support your goals.

eBook: Download the Cell Therapy Handbook

Explore the new cell therapy handbook from Thermo Fisher Scientific.

Whitepaper: Catalent Pulmonary & Nasal Delivery Capabilities Sheet

Did you know Catalent has newly expanded in-house capabilities spanning clinical and commercial scale manufacturing for DPIs, unit-dose, bi-dose and preserved multi-dose nasal sprays?

eBook: Orally Inhaled & Nasal Drug Delivery: A Pipeline of Opportunities

Orally Inhaled & Nasal Drug Delivery: A Pipeline of Opportunities

Whitepaper: Intranasal Drug Product Development: Formulation to Manufacturing

What are key considerations for intranasal delivery in the treatment of acute and chronic conditions?

Events