US pays Evotech $74M to tackle mpox

Today's Big News

Jul 5, 2023

AstraZeneca stock slides as pivotal lung cancer readout on Daiichi-partnered ADC spooks investors


AbbVie sends SHP2 deal back to port, following Big Pharma peer in retreating from target


Evotec's latest DOD contract provides $74M to tackle mpox


Protagonist, J&J oral psoriasis drug falls short of injectables but gets close enough to spur phase 3


Windtree's hypertension med snarled in Catch-22 as hunt for partners comes up dry


Sensorion candidate reduces hearing loss in small midphase trial, offering hope after earlier flop


Researchers find 'highly synergistic' combo featuring Mirati's Krazati in pancreatic cancer models

The Top Line Podcast: don’t miss out on the newest episode where we discuss ASCO data, rising health tech stars, and more. Listen now.

 

Featured

AstraZeneca stock slides as pivotal lung cancer readout on Daiichi-partnered ADC spooks investors

AstraZeneca and Daiichi Sankyo’s attempt to repeat the success of Enhertu has delivered its first phase 3 data. The antibody-drug conjugate improved progression-free survival in lung cancer patients but, with the partners yet to share numbers and “some” patients suffering fatal adverse events, shares in AstraZeneca fell almost 6% in early trading in London.
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July 18-19, 2023 | Jersey City, NJ
 

Top Stories

AbbVie sends SHP2 deal back to port, following Big Pharma peer in retreating from target

Once one of the hottest vessels in the pharma fleet, SHP2 inhibitors are starting to retreat from the seas as AbbVie joins the list of companies ending work on a collaboration with Jacobio to develop therapies for the target.

Evotec's latest DOD contract provides $74M to tackle mpox

Evotec has secured yet another contract from the Department of Defense. This time the U.S. government is committing $74 million for the development of monoclonal antibodies against mpox, chickenpox and smallpox.

Protagonist, J&J oral psoriasis drug falls short of injectables but gets close enough to spur phase 3

Protagonist Therapeutics has shared a closer look at midphase data on its Johnson & Johnson-partnered oral peptide psoriasis drug candidate. The efficacy fell short of the high bar set by injectable treatments but, with the candidate offering the convenience of oral delivery, a phase 3 program is planned.

Windtree's hypertension med snarled in Catch-22 as hunt for partners comes up dry

Despite a two-year search for licensing partners for its hypertension med, Windtree Therapeutics has found itself in a Catch-22 situation that means development of the drug is stalled for the time being.

Sensorion candidate reduces hearing loss in small midphase trial, offering hope after earlier flop

Sensorion’s bid to rebuild confidence in its hearing loss drug candidate SENS-401 has gathered another data point. After seeing the small molecule fail in one indication last year, the French biotech has now provided very early evidence that it may protect against hearing loss in another setting.

Researchers find 'highly synergistic' combo featuring Mirati's Krazati in pancreatic cancer models

A new study from researchers at the University of California San Diego School of Medicine has found one potentially beneficial combo for pancreatic cancer: Mirati Therapeutics' KRAS inhibitor adagrasib, known as Krazati, and Boehringer Ingelheim’s ERBB gene inhibitor afatinib, trade name Gilotrif.

Boehringer Ingelheim launches first interchangeable biosimilar to AbbVie's Humira

Boehringer Ingelheim's Cyltezo stands out from the crowd because it's the only Humira biosimilar to carry an interchangeability designation.

Medtronic finds hacking risk in heart device data management system

Medtronic has identified a vulnerability that could potentially allow hackers to access the cardiac device data stored in its Paceart Optima data workflow systems.

Novartis sells off dry eye disease med Xiidra, other ophthalmology assets to Bausch + Lomb for $2.5B

Novartis is passing off the dry eye disease drop Xiidra to eye health specialist Bausch + Lomb in a $2.5 billion deal, another step in the company's overhaul as it focuses on five core areas. 

CMS proposes $375M cut to home health Medicare payments in 2024

The Biden administration issued a proposal Friday to cut reimbursements to home health providers by 2.2% next year, or an estimated $375 million less than 2023 payment levels.
 
Fierce podcasts

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'The Top Line': The American Diabetes Association's annual conference, plus this week's headlines

This week on "The Top Line," we discuss the American Diabetes Association's annual conference, plus a statement about transgender care, light therapy, and the rest of the week's headlines.
 

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