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July 10, 2018

Today's Rundown

Featured Story

Second positive trial sets up filings for Acceleron’s blood disorder drug luspatercept

Acceleron and Celgene have the second phase 3 trial they wanted for beta thalassemia drug luspatercept, setting up filings in the U.S. and Europe for the first half of 2019.

Top Stories

Wellcome creates £250M fund to make big, risky bets

The Wellcome Trust has created a £250 million ($331 million) nonprofit fund to bankroll high-risk, high-reward research. Wellcome sees the fund accelerating the progress of early-stage projects that may struggle to secure traditional grants or venture investments.

Immunocore’s CMO jumps to Carl June’s gene-editing T-cell developer, Tmunity Therapeutics

Genetically engineered immunotherapy developer Tmunity Therapeutics has brought on Immunocore’s Christina Coughlin to be its chief medical officer and executive vice president, as the company gears up to move its T-cell therapies through early stage studies targeting solid and liquid tumors.

After rosiptor's phase 3 rout, Aquinox to cut staff by 53%

Aquinox Pharmaceuticals will cut its workforce by 53% and shutter its site in San Bruno, California, in a bid to stay alive after it dumped its bladder pain drug, rosiptor.

BioNTech, Genevant form mRNA pacts in rare diseases, oncology

BioNTech and Genevant Sciences have entered into a broad, multipiece partnership. The agreement sets the companies up to work together on five programs targeting rare diseases and another five against cancers.

Antibody developer Vaccinex files $46M IPO to support its NSCLC, Huntington’s studies

Rochester, New York-based antibody developer Vaccinex hopes to raise $46 million in an IPO, listing on the Nasdaq under the symbol VCNX. The clinical-stage company focuses on monoclonal antibodies and antibody-drug conjugates targeting cancer, autoimmune disorders and neurodegenerative diseases.

Torque's T cell 'backpacks' boost immune attack against solid tumors in mice

T-cell therapies have generated enthusiasm because of their high response rates in patients with lymphoma and leukemia, but the technology has proven difficult to translate to solid tumors. MIT researchers have developed nanoparticles with drug payloads that enhance the cells' tumor-killing power without causing off-target effects.

Enrollment Showcase

SBMI Now Offering an Online Graduate Program in Bioinformatics

UTHealth SBMI now offers a M.S. track in clinical and translational bioinformatics.

Resources

[Whitepaper] eClinical Landscape Study - CRO Report from Tufts Center for the Study of Drug Development

See results from the Tufts eClinical Landscape Study – CRO Report on current data management practices, goals, and challenges for contract research organizations (CROs).

[Survey] 2018 eClinical Technology Solutions Survey

Take this anonymous 10-minute survey to share your thoughts on leading eClinical technology solutions and earn up to $55 honoraria. Take the survey now!

[Whitepaper] Digitizing the Global Life Sciences Supply Chain: The Critical Role of Digital Transaction Management

Life science companies are experiencing a significant transformation in how they bring new products to market.

Events

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