AstraZeneca joins IRA lawsuit bandwagon

Today’s Big News

Aug 25, 2023

On a roll, Novo's star obesity drug Wegovy shows benefits in patients with heart failure


RayzeBio plans IPO to push radiotherapy 'pipeline-in-a-product' through phase 3


Paragonix’s pressure-controlled lung transplant system nets FDA green light


Another Keytruda-Lenvima ambition is dashed as Merck, Eisai end head and neck cancer trial


Merck bets big on oral PCSK9 inhibitor, putting 6-year outcome study at heart of phase 3 program

 

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On a roll, Novo's star obesity drug Wegovy shows benefits in patients with heart failure

In a phase 3 study, semaglutide at the 2.4 mg dose bested placebo at reducing symptoms and physical limitations in patients with obesity and heart failure with preserved ejection fraction. The drug also led to greater improvements in exercise function and more weight loss versus a dummy drug, according to study results published in The New England Journal of Medicine Friday.
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Top Stories

RayzeBio plans IPO to push radiotherapy 'pipeline-in-a-product' through phase 3

RayzeBio has already persuaded investors to hand over more than $400 million to pursue its targeted radiation approach to treating cancer. Now, with its lead product in phase 3 trials, the biotech is eyeing up an IPO to push its plans forward.

Paragonix's pressure-controlled lung transplant system nets FDA green light

To simply describe it as an upgrade over the traditional ice-packed, off-the-shelf cooler is an understatement.

Another Keytruda-Lenvima ambition is dashed as Merck, Eisai end head and neck cancer trial

Add another failed trial to the list of setbacks for Merck and Eisai’s combination of Keytruda and Lenvima. The companies have decided to shut down a phase 3 study testing the PD-1/TKI combo in first-line head and neck cancer.

Merck bets big on oral PCSK9 inhibitor, putting 6-year outcome study at heart of phase 3 program

Merck & Co. is betting big on its oral PCSK9 inhibitor. Buoyed by midphase results, the Big Pharma has kicked off a clutch of late-stage studies including a cardiovascular outcomes trial that will follow patients for around six years.

AstraZeneca jumps on IRA litigation bandwagon, raising concerns over 'unintended consequences' in rare disease R&D

The company cited concerns with the law's consequences for orphan drug development. AstraZeneca becomes the sixth drugmaker to file suit against the IRA.

Y chromosome fully sequenced for the first time, revealing its secrets from 'telomere-to-telomere'

With the help of advanced algorithms and DNA sequencing techniques, scientists have decoded the Y chromosome in full for the first time.

Cleveland Clinic spinout VisionAir, a maker of 3D-printed airway stents, acquired by Theken

Theken Companies, an Ohio-based family of medical implant makers, has found the next member of its family within the Buckeye State.
 
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