Secrets of the Y chromosome revealed

Today’s Big News

Aug 25, 2023

RayzeBio plans IPO to push radiotherapy 'pipeline-in-a-product' through phase 3


Merck bets big on oral PCSK9 inhibitor, putting 6-year outcome study at heart of phase 3 program


Y chromosome fully sequenced for the first time, revealing its secrets from 'telomere-to-telomere'


Chutes & Ladders—Leaps by Bayer chief jumps to Bayer, too; Exelixis finds a new CMO

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Featured

RayzeBio plans IPO to push radiotherapy 'pipeline-in-a-product' through phase 3

RayzeBio has already persuaded investors to hand over more than $400 million to pursue its targeted radiation approach to treating cancer. Now, with its lead product in phase 3 trials, the biotech is eyeing up an IPO to push its plans forward.
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Top Stories

Merck bets big on oral PCSK9 inhibitor, putting 6-year outcome study at heart of phase 3 program

Merck & Co. is betting big on its oral PCSK9 inhibitor. Buoyed by midphase results, the Big Pharma has kicked off a clutch of late-stage studies including a cardiovascular outcomes trial that will follow patients for around six years.

Y chromosome fully sequenced for the first time, revealing its secrets from 'telomere-to-telomere'

With the help of advanced algorithms and DNA sequencing techniques, scientists have decoded the Y chromosome in full for the first time.

Chutes & Ladders—Leaps by Bayer chief jumps to Bayer, too; Exelixis finds a new CMO

Leaps by Bayer's Juergen Eckhardt adds innovation role at Bayer. Exelixis has named Amy Peterson as its new chief medical officer, replacing Vicki Goodman. Mirati CFO follows CEO out of the exits.

Fierce Pharma Asia—Moderna's cancer combo plan; GSK's trial win; Glenmark's DOJ deal

Moderna is considering pairing an mRNA cancer vaccine candidate with a CAR-T therapy from China's CARsgen. GSK's Shingrix showed 100% efficacy in a Chinese post-marketing trial. Glenmark and Teva have reached a settlement with U.S. prosecutors over price-fixing charges.

On a roll, Novo's star obesity drug Wegovy shows benefits in patients with heart failure

In a phase 3 study, semaglutide at the 2.4 mg dose bested placebo at reducing symptoms and physical limitations in patients with obesity and heart failure with preserved ejection fraction. The drug also led to greater improvements in exercise function and more weight loss versus a dummy drug, according to study results published in The New England Journal of Medicine Friday.

Cigna eliminates prior auth requirements for 25% of codes

Cigna is eliminating prior authorization requirements from 600 diagnostic codes in a bid to streamline the experience for both members and providers.

Cabometyx study ends early after researchers see 'dramatic' benefits in neuroendocrine tumors, Exelixis says

Exelixis' drug proved its worth in treating advanced pancreatic and extra-pancreatic neuroendocrine tumors, so much so that an independent board unanimously recommended an early stop.

Another Keytruda-Lenvima ambition is dashed as Merck, Eisai end head and neck cancer trial

Add another failed trial to the list of setbacks for Merck and Eisai’s combination of Keytruda and Lenvima. The companies have decided to shut down a phase 3 study testing the PD-1/TKI combo in first-line head and neck cancer.
 
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Resources

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Plan for success with your process liquid and buffer preparation

Learn how process liquids and buffers impact your total cost of ownership (TCO) and how outsourcing can revolutionize your approach, ensuring quality standards and improving productivity.
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Key Drivers of Sales Force Strategy in Oncology

In oncology, traditional methods for determining sales force size & structure are no longer appropriate. This paper describes the multiple drivers of sales strategy in oncology markets today.
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Reduce chemical lead times with just-in-time delivery

Learn how the right chemical inventory strategy helped save a mid-size CDMO millions of dollars while securing a stable supply of products with just-in-time delivery.
 

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