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Today's Rundown

Featured Story

Pfizer's abrocitinib beats blockbuster Dupixent in phase 3 eczema trial, but key questions remain

Rivals are closing in on Sanofi and Regeneron’s Dupixent. With AbbVie’s Rinvoq having already bested Dupixent in atopic dermatitis, Pfizer has now chalked up its own efficacy win over the blockbuster incumbent without sharing key details of safety data that could shape the category.

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Top Stories

Laronde banks $440M to ramp up RNA-based meds that could turn cells into protein factories

Laronde launched out of Flagship Labs this year with a lofty vision: to deliver as many as 100 new RNA medicines over the next 10 years. Now, it’s fueling that goal with a major $440 million round. The massive investment also reflects a broader interest in new RNA technologies thanks to the rapid success of two mRNA vaccines against COVID-19.

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Bone Therapeutics' lead program falls short in knee osteoarthritis

Bone Therapeutics is mulling options for its lead program after the osteoarthritis treatment failed to beat placebo or an active comparator treatment in a phase 3 study involving more than 700 patients.

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Sponsored: Accelerating Outcomes with a Pancreatic Cancer Adaptive Platform through Collaboration and IRT Expertise

When your goal is to identify effective and ineffective treatments more quickly than traditional trials through a Complex Innovative Design, the right IRT system is crucial.

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SPAC backs Revelation to tackle respiratory viral infections

The spectrum of SPAC mergers encompasses all deal sizes. While multibillion-dollar mergers have defined the space in 2021, Revelation Biosciences is joining with Petra Acquisition to create a Nasdaq-listed company with the relatively Lilliputian enterprise value of $128 million. 

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Brain cancer biotech Ziopharm snaps up new CEO from Kuur Therapeutics

Kevin S. Boyle has joined cell and gene therapy biotech Ziopharm as CEO. Boyle previously led Kuur Therapeutics and his hiring was done in conjunction with two leadership promotions.

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Genome Medical plots growth spurt with back-to-back $60M venture raise, GeneMatters acquisition

In the latest phase of its mitosis, Genome Medical took a two-pronged approach: Alongside raking in $60 million in new financing, it also made a bid for GeneMatters, a Minneapolis-based provider of virtual genetic counseling services.

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Thwarting a cancer-promoting enzyme with a 2-pronged strategy to induce cell death

Cancer cells adapt to a harsh, acidic environment by spewing enzymes that neutralize the acid. Canadian researchers discovered that inhibiting one of those enzymes, Carbonic Anhydrase IX (CAIX), while simultaneously promoting a form of cancer-cell death, slows tumor growth.

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Industry Voices—Why the COVID-19 pandemic was a watershed moment for machine learning

Times of crisis spark innovation and creativity, as evidenced in the way organizations have come together to innovate for the greater good during the COVID-19 pandemic. We now have the opportunity to build on our learnings from the past year to apply machine learning to help address several underlying problems that plague the healthcare and life sciences communities.

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Roche pulls Tecentriq breast cancer nod after post-approval trial flop

Roche’s Tecentriq was heralded just two years ago as the first PD-1/L1 treatment to win an FDA nod in triple-negative breast cancer. Now, the Swiss pharma is pulling the approval after failing a key post-approval trial.

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Children's Hospital Association asks Biden for federal support as pediatric COVID-19 cases rise

The Children's Hospital Association is directly pleading with President Joe Biden to boost federal support for facilities that are facing an influx of pediatric COVID-19 cases.

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Resources

Whitepaper: Going from Process R&D to Clinical APIs Quickly and Effectively

Read four customer success stories and four success factors that helped move pharmaceutical customers of Cascade Chemistry by Aceto quickly and effectively to clinic with trial-ready APIs.

Webinar: Let A Digital Sherpa Uncomplicate The Path for Patients

Topple barriers to getting patients started on therapy. Guide them with mobile.

eBook: Accelerate recruitment with a decentralized clinical trial strategy

Learn how a decentralized clinical trial strategy improves patient recruitment, reduces drop-out rates, and ultimately streamlines the path to the next trial phase.

Whitepaper: How to build a robust packaging strategy for rapid commercialization

Learn how to build a robust packaging strategy and the key technical considerations in packaging design and operational planning to enable rapid commercialization of pharmaceuticals.

Whitepaper: Understanding the CMC regulatory landscape for cell and gene therapy products

Learn how regulations are changing and key considerations for commercializing cell and gene therapies without sacrificing quality.

Whitepaper: Navigating the Digital Transformation Journey

Uncover the real impact of “digital transformation” with practical advice to help you plan your own transformative journey to a harmonized digital ecosystem.

eBook: Get solutions to market faster

Read Get to Know Cloud Content Management for Life Sciences and learn how to eliminate silos across all workflows, from R&D to commercialization.

eBrief: Drug Product Process Development: Ensuring a Consistent, High-quality Biologic

Learn about drug product process development challenges and risks, the difference between innovator and biosimilar drug product process development, and more during the drug product process development phase.

Whitepaper: Achieving a Successful Drug Product Technology Transfer

Get insights on key considerations for a successful tech transfer process for manufacturing a biologic drug product, including a case study on overcoming challenges in a process transfer for a sterile diluent.

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