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August 31, 2017

Today's Rundown

  1. Pfizer, Celgene and Roche are climbing pharma VC league table

  2. Daiichi axes $650M pain pact 7 months after FDA setback

  3. Early Keytruda combo data paint Incyte’s epacadostat as a threat to Bristol-Myers’ I-O melanoma franchise

  4. Bayer files longer-acting bleeding candidate to FDA

  5. ‘Hit-and-run’ gene therapy nanoparticles could enhance CAR-T treatments

  6. 'Gentler' CRISPR sheds light on autoimmune disease

  7. Teva takes on Neurocrine with TD nod for Austedo

Featured Story

Pfizer, Celgene and Roche are climbing pharma VC league table

Corporate venture capital has long been an important source of capital for early-stage biotechs and shows no signs of diminishing, with more and more biopharma companies stepping up their investment activity.

Top Stories

Daiichi axes $650M pain pact 7 months after FDA setback

Daiichi Sankyo has cut and run from its $650 million pain alliance with Charleston Laboratories. The decision comes seven months after the FDA knocked back a request for approval of the collaboration’s top prospect.

Early Keytruda combo data paint Incyte’s epacadostat as a threat to Bristol-Myers’ I-O melanoma franchise

Incyte has presented data suggesting its IDO1 enzyme inhibitor dials up the effect Keytruda has on advanced melanoma patients. The interim phase 1/2 readout paints the Incyte-Merck combination as a potential improvement over Bristol-Myers Squibb’s incumbent CTLA-4-PD-1 cocktail.

Bayer files longer-acting bleeding candidate to FDA

German pharma Bayer has sent its BLA to the FDA for its long-acting Hemophilia A medication BAY94-9027.

‘Hit-and-run’ gene therapy nanoparticles could enhance CAR-T treatments

Personalized cancer treatments known as CAR-T cells have dominated the headlines lately, but they are labor-intensive and expensive to make, and they can attack healthy tissues in the body. Fred Hutch scientists have created nanoparticles that could address both those shortcomings.

'Gentler' CRISPR sheds light on autoimmune disease

CRISPR is typically used to edit disease-causing gene mutations, but is increasingly being tapped for broader applications. The latest? Identifying sequences that activate genes, which could help unravel the causes of autoimmune disease.

Teva takes on Neurocrine with TD nod for Austedo

Downtrodden Teva Wednesday got some good news—and Neurocrine got some company. The FDA approved the Israeli drugmaker’s Austedo to treat movement disorder tardive dyskinesia (TD) in adults, marking the med’s second approval. It won its first go-ahead in early April as a therapy for another movement disorder, chorea, which is associated with Huntington’s disease.

Resources

[Webinar] Five ways to make your patient support program a success

Join this webinar to learn how to design, deliver, and measure a successful patient support program. Presented by Nareda Mills, Ashfield's SVP of Patient Services in the US, you’ll discover how to improve adherence and improve patient outcomes using 5 key methods.

[Video] API Discussion with Dr. Robert DeWit, CEO of MPI Research

FierceBiotech interviews Dr. DeWit to discuss a common cause for drug development delays, and strategies to avoid these costly setbacks.

[Webinar] Within-Subject Clinical Trials: Intro to New Methods & Stat. Models

In this webinar, we will introduce the rapidly-evolving within-subject clinical trial (WSCT) methods for early phase evidence generation that require fewer people, less time, and usually less funding than traditional early phase methods.

Events

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