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Today's Rundown

Featured Story

Not waving but drowning: Takeda's blood cancer drug flunks phase 3, dealing further blow to hopes of approval flurry

Takeda’s Wave 1 pipeline is threatening to peter out into a ripple. The latest setback comes from a phase 3 blood cancer clinical trial, which found adding pevonedistat to chemotherapy did nothing to improve event-free survival.

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Top Stories

Exit of Avidity CMO on cusp of first clinical trial sparks stock rout

Investors are taking the departure of Avidity Biosciences’ chief medical officer badly. After learning Jae Kim had left for personal reasons, just days after giving his notice and on the day Avidity posted details of its first study to ClinicalTrials.gov, investors drove the stock down 19%.

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After one HBV flop, Assembly Biosciences forced to drop a hepatitis asset amid safety woes

Assembly Biosciences saw its shares dragged down more than 20% Wednesday evening after it was forced to toss out a midstage hepatitis B treatment due to safety concerns.

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Sponsored: Accelerating Outcomes with a Pancreatic Cancer Adaptive Platform through Collaboration and IRT Expertise

When your goal is to identify effective and ineffective treatments more quickly than traditional trials through a Complex Innovative Design, the right IRT system is crucial.

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Bristol Myers greenlights neurodegenerative medicine from Evotec pact for $20M

Evotec is headed to the bank with a cool $20 million after Bristol Myers Squibb opted in on a neurodegenerative medicine called EVT8683. The licensing opt-in could also trigger $250 million in milestone payments down the line plus royalties on future sales.

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Disc Medicine nabs $90M for blood disease pipeline, new Roche asset

Disc Medicine has raised $90 million in a series B round as it looks to push on with its pipeline of early- to midstage blood disorder assets.

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Baxter's deal for smart hospital bed maker Hill-Rom swells to $10.5B

The deal will see Baxter purchase all of Hill-Rom’s outstanding stock at a price of $156 per share, up from the previous reported offer of $144 apiece and a step above the $150 figure reported earlier this week.

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FDA's new JAK safety restrictions spell trouble for AbbVie's Rinvoq, but to what extent?

AbbVie’s megablockbuster Rinvoq ambition suffers a blow thanks to an updated safety warning and treatment restriction from the FDA. But pharma watchers have different opinions on just how significant the impact may be.

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Biogen's Aduhelm label far exceeds clinical trial population, study says. That could bring real-world surprises

There's "room for surprises" when it comes to the safety of Biogen's Aduhelm because of the company's tightly controlled clinical trials, which recruited a narrower group of Alzheimer's patients compared to the treatment's FDA label, RBC Capital Markets wrote on Wednesday, citing a recent study.

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Healthcare Dealmakers—Ginger, Headspace's $3B merger; UnitedHealth Group and Change Healthcare's DOJ deal

Carbon Health's expanding clinic footprint, Verily's first-ever purchase and more merger and acquisition news from the month of August.

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Whitepaper: Challenging Tradition: The Argument for Integrated Commercialization to Improve Operational Agility

Today’s economics do not allow manufactures to keep making decisions in an antiquated way. They need to challenge tradition & deliver faster, cheaper, successful launches. Learn how.

Whitepaper: High-yield NK cell culture for allogeneic cell therapy applications

Thermo Fisher Scientific introduces a new NK cell culture medium designed to support feeder-free, high-yield growth for cell therapy applications.

Whitepaper: Five Trends to Watch in the European Market Access Environment

This white paper provides a concise overview of the trends currently shaping the market access environment in Europe, as well as the implications for biopharma companies.

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Read four customer success stories and four success factors that helped move pharmaceutical customers of Cascade Chemistry by Aceto quickly and effectively to clinic with trial-ready APIs.

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eBook: Get solutions to market faster

Read Get to Know Cloud Content Management for Life Sciences and learn how to eliminate silos across all workflows, from R&D to commercialization.

eBrief: Drug Product Process Development: Ensuring a Consistent, High-quality Biologic

Learn about drug product process development challenges and risks, the difference between innovator and biosimilar drug product process development, and more during the drug product process development phase.

Whitepaper: Achieving a Successful Drug Product Technology Transfer

Get insights on key considerations for a successful tech transfer process for manufacturing a biologic drug product, including a case study on overcoming challenges in a process transfer for a sterile diluent.

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