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September 12, 2019___

Today's Rundown

Featured Story

Tocagen fails brain cancer test, sets about 'operational review' as shares routed

It was always going to be a long shot, given how tough brain cancer is to treat and the litany of failures left in its wake, but Tocagen, perhaps inevitably, has seen its attempt flop, leading to a review of its operations.

Top Stories

Moderna guides 2 mRNA assets through early clinical tests

Moderna has shared data from two phase 1 trials of mRNA candidates, providing early evidence it could succeed in making its own drugs. The trials tested cytomegalovirus vaccine mRNA-1647 and chikungunya virus candidate mRNA-1944.

'No surprise'—FDA sticks to the script ahead of Aimmune peanut allergy AdComm

“Briefing docs right down the middle of the fairway,” wrote Piper Jaffray analysts of Aimmune's peanut allergy treatment, Palforzia. The Allergenic Products Advisory Committee will meet on Friday to review the treatment.

[Sponsored] What Makes an Oncology Clinical Trial Site Stand Out from the Competition?

Patients want the best cancer therapies, and sites that enable clinical trials are the ones that can access those new drugs faster. Here’s how

Roche's satralizumab cuts relapse risk in rare disease phase 3

In a phase 3 trial of its neuromyelitis optica spectrum disorder treatment satralizumab, Roche linked the anti-IL-6 antibody to a 55% reduction in the risk of relapse, showing the drug works but with scope to question how it will do against rivals.  

J&J multiple sclerosis hopeful tops Sanofi's Aubagio at reducing relapse, fatigue

In a study testing a 20 mg dose of Janssen's multiple sclerosis drug ponesimod against a 14 mg dose of Sanofi's Aubagio in adults with the relapsing form of the disease, ponesimod cut the number of disease flare-ups by 30%.

Many cancer drugs don't hit their intended targets: study

Several cancer drug candidates in clinical trials are designed to kill tumor cells by attacking certain targets, but they actually work in other ways, a study by Cold Spring Harbor Laboratory has found.

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Resources

[Whitepaper] How Can You Avoid the Fallout From Incompatibility Between Your API and Its Formulation?

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[Article] Why Market Leaders Outsource IT Requirements For A Competitive Edge

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[Whitepaper] From Complex to Controlled: Advanced Data Management Strategies for Advanced Therapies

Developing a cell therapy, gene therapy, or personalized cancer vaccine? Modern data management makes a critical difference in operational and regulatory outcomes. This whitepaper will help your team leverage the latest data strategies for success.

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[Whitepaper] What's Your Lab Trying to Tell You? Listen with Connected IoT Sensors

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[Whitepaper] Prevent the Real World From Derailing Your Clinical Trial: Focus on Protocol Design

Want to be sure your renal research protocol design is fit for the real world?

[Whitepaper] Optimizing Operations in Multiproduct Pharma Manufacturing Facilities

Vetting CDMOs but unsure what to look for in prospective partners’ multiproduct facilities?

[Report] Future of clinical trials: From real-time data to algorithmic trials

Clinical trials are one of the pharma industry’s most painful and costly processes. Read how technology could transform the trial process from nine years to a matter of hours.

[Whitepaper] Considerations and Options for Prefilled Syringes

Check out Baxter BioPharma Solutions’ whitepaper to learn considerations and options for developing a product in a prefilled syringe.

[Article] Sales Compensation: 7 Trending Topics

From sales headcount and budgets to new product launches and saying “yes” to millennials, hear the top 7 topics that are trending in sales compensation.

[Whitepaper] The Supply Chain Planning Cure for Everything from Product Expirations to Patent Cliffs

Download this life sciences industry spotlight to discover how concurrent planning can help you overcome complex supply chain challenges to drive down costs and improve efficiency.

[Case Study] Clinical Supply Management

Download the case study to learn about the clinical supply management tools that helped a small sized pharma company during phase III of a multi-arm oncology study.

[Video] Demand Led Services and Clinical Supply Efficiency

Watch a short video on demand led supply model. It is designed to meet the needs of patients, clinical sites, clinical team and sponsors and results in shorter lead time, less waste, less stock out risk and no booklet labels.

[eBook] Strategies for Efficient Clinical Supply Management and Forecasting

Download the eBook to explore a proactive approach for clinical supply management.

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