The road to post-lockdown life is already filled with twists and turns.

From troubling developments around the AstraZeneca vaccine to Britain and the EU coming to blows over the jabs, the battle against Covid-19 looks set to cause even more chaos before it is won.

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As a Telegraph subscriber, you’ll gain an expert, up-to-the-minute perspective on the latest vaccination developments. The European Medicines Agency has concluded that the AstraZeneca vaccine is “safe and effective”, clearing it for use in the EU despite many nations earlier suspending the inoculation. Although one British man has died and four others developed blood clots after receiving the jab, we’ll talk you through the numbers behind the concerns and explain why it’s still safe to have the vaccination.

The UK’s vaccine rollout will be paralysed next month, however, due to supply shortages. No more first appointments will be booked for the jabs in April, while five million UK-bound AstraZeneca doses are being held up “by the Indian government”. In the meantime, Ursula Von der Leyen has been accused of “acting like a dictator” after threatening to block supplies to the UK, with Matt Hancock warning of “very significant consequences” should the EU do so.

Ambrose Evans-Pritchard reflects on Von der Leyen’s threats as he writes: “Mirabile Dictu: global capital is leaving Europe and coming to Britain”. Allister Heath examines our capital’s “self-destructive shift Left”, warning “The Tories have abandoned Sadiq Khan's London to a doom-spiral of permanent decline”. Robin Aitken questions whether the BBC’s move North is enough to change its mindset, stating “You can take the BBC out of London, but you can’t take London out of the BBC”. Nick Allen, meanwhile, looks to America, predicting “Joe Biden won’t run for a second term, and everyone knows it”.

Elsewhere, ties have been strained between the US and Russia, with Vladimir Putin mocking President Biden for labelling him a “killer”, responding “it takes one to know one”. Johnny Depp has launched his appeal against last year’s High Court judgment that he assaulted his ex-wife, with Amber Heard’s claim that she donated her 5.5million divorce settlement to charity branded a “calculated lie”. And don’t miss our team’s definitive list of our 25 favourite funds to fill your pension and Isa with before the tax year ends.

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