Anaptys seeks partner after ph. 3 win

Today’s Big News

Oct 9, 2023

Eikon cuts staff 'to become more efficient,' letter from CEO Roger Perlmutter reveals


After pandemic sugar rush, a market 'hangover' opens biotech to funding approaches steeped in stigma


Chasing Boehringer, Anaptys hits goal in pivotal rare skin disease trial, plans outlicensing deal


Novartis-backed AstronauTx heads off for Alzheimer's mission with $61M series A


Doudna lab finds chromosome loss from CRISPR-Cas9 is common—and swapping steps is key to stopping it

The Top Line Podcast: Don’t miss out on the newest episode. Listen now.

 

Featured

Eikon cuts staff 'to become more efficient,' letter from CEO Roger Perlmutter reveals

Eikon Therapeutics, a biotech that snatched several big-name executives from Merck & Co. and raked in some of the largest financing rounds in recent memory, has cut staff in an effort to “become more efficient.”
 

Top Stories

After pandemic sugar rush, a market 'hangover' opens biotech to funding approaches steeped in stigma

You're not going to hear a private biotech trumpeting a down round as they announce a new batch of funding, but industry experts say the broader market trend has seeped into the sector. That's because a down round used to ring red-hot alarm bells. But as valuations change, investors say the meaning of a down round might too.

Chasing Boehringer, Anaptys hits goal in pivotal rare skin disease trial, plans out-licensing deal

AnaptysBio has set the stage for negotiations over its rare skin disease drug candidate, delivering phase 3 data that suggest the asset can challenge Boehringer Ingelheim in generalized pustular psoriasis (GPP).

Changing the Pharmaceutical Commercialization Landscape

In a dynamic landscape, three emerging trends have the power to reshape the complexities of pharmaceutical commercialization.

Novartis-backed AstronauTx heads off for Alzheimer's mission with $61M series A

While the final frontier of Alzheimer’s work is patrolled by U.S. Big Pharmas like Eli Lilly and Biogen, the U.K. is sending out its own mission in the form of AstronauTx.

Modeling patient insights to make the most of clinical trials

Greg Lever, Director within the IQVIA Applied Data Science Center, reveals how modeling technology is being used to unlock value and enhance the experience of trial participants.

Doudna lab finds chromosome loss from CRISPR-Cas9 is common—and swapping steps is key to stopping it

The lab of Nobel laureate Jennifer Doudna showed that CRISPR can lead to a phenomenon known as chromosome loss in T cells, but that preventing it lies in the order of gene editing operations.

Bristol Myers Squibb buys Mirati for up to $5.8B as I-O giant branches out into targeted therapy for cancer

After years serving as a rumored target of Big Pharma M&A, Mirati Therapeutics has finally made its sale a reality. The buyer, Bristol Myers Squibb, will pay up to $5.8 billion for the KRAS drugmaker.

QHP buys Applied StemCell, adding cell and gene therapy specialist to pharma service portfolio

QHP Capital has slotted another company into its portfolio of contract service providers, snapping up cell and gene therapy specialist Applied StemCell and outlining plans to support its expansion.

Medtech faces looming 'innovation gap' amid plummeting M&A, IPO, VC activity: EY report

Revenues across the medtech industry clocked in at $573 billion for all of 2022, marking annual growth of just 3.5%—the industry’s lowest rate since 2015.

Alnylam abandons Onpattro expansion in US as FDA spurns rare heart disease bid

Despite an endorsement from an advisory committee, the FDA has come to a different conclusion on the benefit-risk profile for Alnylam’s Onpattro in the rare heart disease transthyretin amyloidosis cardiomyopathy (ATTR-CM).

HLTH23, Day 1: Startups, providers, payers and retail giants flock to Vegas

The latest news and updates from the HLTH 2023 conference: Uber and Optum team up to simplify access to Medicare Advantage supplemental benefits.

Novo Nordisk's weight-loss drugs pose small risk of severe stomach complications: study

People who use Novo Nordisk’s popular weight-loss drugs are taking on a small risk of developing severe stomach problems, according to research conducted by the University of British Columbia. The investigation indicates a link between Novo’s GLP-1 products and gastroparesis, pancreatitis and bowel obstruction. Still, the investigators emphasized that the risk was very small.
 
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Resources

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