Turnstone shrinks headcount by 60%

Today’s Big News

Oct 11, 2024

Gilead gives up on $15M MASH bet with Yuhan after mulling preclinical data


'Impossible' FDA adcomm ends in favor of Stealth’s ultra-rare disease med


Turnstone lays off 60% of staff, shakes up C-suite to keep cancer cell therapy on track


Upstream swells IPO to $255M as it prepares to join Nasdaq along with CAMP4


Sanofi flunks midphase multiple sclerosis study, dealing another blow to Denali pact


After axing its sole clinical prospect last year, Alaunos cuts ties with Precigen


Capricor cell therapy improves cardiac and upper limb function in phase 2 Duchenne muscular dystrophy victory lap


Chutes & Ladders—Lilly goes all-in on AI with new exec position

The Top Line Podcast: Don’t miss out on the newest episode. Listen now.

 

Featured

Gilead gives up on $15M MASH bet with Yuhan after mulling preclinical data

The U.S. drugmaker has “mutually agreed” to terminate its collaboration and license agreement with South Korean biotech Yuhan for a pair of MASH therapies.
 

Top Stories

'Impossible' FDA adcomm ends in favor of Stealth’s ultra-rare disease med

Difficult. Impossible. Agonizing. Worse than voting in the national election. All those descriptors were used today by FDA advisory committee members when asked to vote on an investigational rare disease therapy.

Turnstone lays off 60% of staff, shakes up C-suite to keep cancer cell therapy on track

Turnstone Biologics is reducing its headcount by 60% and shaking up its C-suite in order to keep the cash flowing to its sole clinical-stage candidate.

Upstream swells IPO to $255M as it prepares to join Nasdaq along with CAMP4

Upstream Bio has swollen its IPO to $255 million as the company joins CAMP4 Therapeutics this morning in becoming the latest biotechs to list on the Nasdaq.

Sanofi flunks midphase multiple sclerosis study, dealing another blow to Denali pact

Sanofi has stopped a phase 2 trial of the Denali Therapeutics-partnered oditrasertib in multiple sclerosis. The French drugmaker tore the RIPK1 inhibitor trial from its list of active studies after failing to meet its primary and secondary endpoints, dealing a further blow to a collaboration with a troubled history.

After axing its sole clinical prospect last year, Alaunos cuts ties with Precigen

Alaunos Therapeutics is axing an agreement with Precigen, giving up licensing rights to a personalized T-cell platform.

Capricor cell therapy improves cardiac and upper limb function in phase 2 Duchenne muscular dystrophy victory lap

Capricor Therapeutics is taking a victory lap for their phase 2 Duchenne muscular dystrophy (DMD) trial. At 3 years, the San Diego-based company’s cell therapy deramiocel improved patients’ left ventricular ejection fraction and ability to use their upper limbs.

Chutes & Ladders—Lilly goes all-in on AI with new exec position

Eli Lilly is ramping up its efforts to incorporate AI across its business by appointing Thomas Fuchs to the new role of chief AI officer. In his new job, Fuchs will lead AI initiatives across Lilly’s drug discovery, clinical trials, manufacturing, commercial activities and internal functions.

Activist investor Starboard accuses Pfizer of strong-arming former execs into backing CEO Bourla ahead of strategy meeting

After initially supporting a meeting with activist investor Starboard Value, Pfizer's former CEO and CFO publicly changed their tune after being threatened with litigation by Pfizer, Starboard alleges.

Deep learning AI model scans 'dark matter' of genomic data to find 70,000 never-before-seen RNA viruses

To find RNA viruses hiding in genomic “dark matter,” researchers took advantage of one thing they all have in common: the RNA polymerase enzyme.

Roche burnishes breast cancer portfolio with FDA approval for Itovebi, a threat to Novartis and AZ

As Roche comes under competitive pressure on its breast cancer business, the Swiss company hopes a new drug will add a 2-billion-Swiss-francs luster to the once high-flying portfolio.

Fierce Pharma Asia—AstraZeneca-CSPC heart med deal; Astellas' gene therapy pact, new cell therapy site

AstraZeneca has bagged a cardiovascular disease candidate from China's CSPC Pharma in a deal potentially worth $2 billion. Astellas is shuffling its cell therapy research team and investing in a dementia gene therapy candidate.
 
Fierce podcasts

Don’t miss an episode

A revival in neuro therapeutics

This week on "The Top Line," Fierce Pharma's Fraiser Kansteiner chats with industry leaders about the surge in neuroscience investment, breakthroughs and future targets in neuropharmaceuticals.
 

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