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October 27, 2017

Welcome to FierceLifeSci Weekly Digest, your roundup of the biggest and most popular stories from each of our publications.

Featured Story

Merck, citing 'ebb and flow' in priorities, plots 1,800 sales layoffs and new chronic care focus

Merck & Co. plans to jettison three U.S. sales teams and 1,800 associated staffers while creating a new, 960-employee chronic care force.

Top Stories Of The Week

Celgene cans phase 3 trial of $710M Crohn’s drug GED-0301

Celgene has scrapped a phase 3 trial of inflammatory bowel disease drug GED-0301 after it failed to clear an interim futility review. The decision leaves Celgene facing the prospect of canning a drug it paid $710 million upfront for in 2014.

GlaxoSmithKline wins blockbuster green light for Shingrix, its new shingles vaccine

GlaxoSmithKline has the official go-ahead for its next big launch. Late Friday, the FDA approved the company's new shingles vaccine, Shingrix, setting up a market duel with blockbuster implications between GSK and Merck.

High-dose Gilead/Nimbus NASH drug hits liver fat

In new phase 2 data published today, Gilead says a higher dose of its NASH drug saw statistically significant reductions in liver fat, although a lower dose missed the mark.

Celgene takes its most aggressive price hikes yet on Revlimid, Pomalyst: analyst

Defying critics in Congress and elsewhere, Celgene hiked the list prices of key cancer medications Revlimid and Pomalyst by 9% this month, taking their cumulative increases for the year into ranges that many Big Pharma peers have pledged to avoid.

After ceasing Animas insulin pump sales in U.S., Canada, J&J to lay off 297

Earlier this month, Johnson & Johnson announced it would stop making and selling its Animas insulin pumps in the U.S. and Canada. Now, a WARN notice shows, the company will lay off 297 employees in Pennsylvania.

GlaxoSmithKline eyes Pfizer's OTC unit. But will a buy imperil its dividend?

GlaxoSmithKline said Wednesday that it's looking hard at Pfizer’s up-for-sale OTC unit—but that was bad news to analysts worried about the fate of the company’s dividend.

Improving immuno-oncology with electronics-inspired gene 'circuits'

Immunotherapy is promising, but identifying tumor-specific antigens for immuno-oncology treatments to target has proven challenging. Now, using a gene circuit encoded in DNA, scientists at MIT have found a way to identify cancer cells more accurately and stimulate the immune system more effectively.

Dr. Reddy's, fighting to recover from FDA warning letter, recalls 500K heartburn tablets

Still struggling to turn its manufacturing around, Dr. Reddy's is recalling 569,000 store-brand famotidine tablets in the U.S., thanks to failed tests for impurities and degradation. It's the India-based company's second recall of the same medication since last July.

Parexel aims for R&D excellence with Microsoft tie-up

Major CRO Parexel has teamed up with Microsoft to create a new cloud technology alliance aimed at speeding up drug research. The pair said they are hoping to “drive digital transformation” of biopharma through the pact, which will combine Parexel’s drug development work with Microsoft’s cloud computing tech Azure.

Enrollment Showcase

Online Graduate Programs Designed for Your Career

Drexel University’s online graduate programs in biomedicine, clinical research, drug discovery, and molecular medicine were developed with working professionals in mind, providing you with the education, practical skills, and competitive edge you need to be successful in your career. Learn more.

Resources

[Whitepaper] Veeva 2017 Annual CRO Report: CROs lead the drive to a unified clinical model

CROs are leading an industry wide shift to modernize clinical systems and clinical trial processes.

[Whitepaper] Industry Report: Clinical Operations Leaders Reveal Need for Change

The 2017 Unified Clinical Operations Survey finds that 99% of respondents report the need to unify their clinical applications, including CTMS, EDC, eTMF, and study start-up.

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