Kriya makes another gene therapy buy

Today's Big News

Nov 16, 2022

Novartis halts phase 1 cancer trial of CD73 antagonist over efficacy, but combo studies continue

NextCureLegoChem join big-league rivals in antibody-drug conjugate race

Kriya relies on M&A toolkit once more to build out gene therapy pipeline, this time in neurology

CureVac rethinks lead cancer program after posting PD-1 data, limiting future studies to mRNA vaccine combos

Rafael pivot halts R&D, lays off staff in hopes of revival following phase 3 fails

Kill the weeds, save the flower: New treatment possibility emerges for fatal childhood brain cancer

 

Featured

Novartis halts phase 1 cancer trial of CD73 antagonist over efficacy, but combo studies continue

Novartis has halted a phase 1 trial of its CD73 antagonist due to a low likelihood of efficacy, although the Big Pharma will continue to explore the therapy’s potential as part of a combo regimen.
 

Top Stories

NextCure, LegoChem join big-league rivals in antibody-drug conjugate race

NextCure has found a new use for its anti-B7-H4 antibody NC762. By partnering with Korea’s LegoChem Biosciences, the biotech plans to aim an antibody-drug conjugate at the oncology target and join an R&D race featuring AstraZeneca, Mersana Therapeutics and Seagen.

Kriya relies on M&A toolkit once more to build out gene therapy pipeline, this time in neurology

Gene therapy biotech Kriya Therapeutics is continuing its acquisition streak to build out a pipeline, this time with a focus on the brain. The North Carolina-based biotech is buying Redpin Therapeutics to expand, acquiring treatments for epilepsy and trigeminal neuralgia. There were no dollar figures included in Wednesday’s deal announcement and a press contact for Kriya said financial details weren’t being disclosed. 

Patients want more info about clinical trials. Here’s how biopharma can help

While the industry has yet to address a big barrier to trial enrollment—low patient knowledge—the good news is that patients want to learn more, according to survey data from Phreesia Life Sciences.

CureVac rethinks lead cancer program after posting PD-1 data, limiting future studies to mRNA vaccine combos

CureVac is rethinking development of immunity activator CV8102 in the wake of the publication of data from a checkpoint inhibitor combination trial, vowing to only consider further clinical studies if the drug candidate is paired with “a defined mRNA cancer vaccine.”

Promise of mRNA technology creates new manufacturing challenges

Every mRNA manufacturing process step adds complexity and cost, so it’s important to ensure steps are compatible and integrated with each other. Explore each intertwined step in this infographic.

Rafael pivot halts R&D, lays off staff in hopes of revival following phase 3 fails

Rafael Holdings is laying off staff and giving up on early-stage R&D efforts that were touted as the company’s main focus less than a year ago, as it pivots to seeking out investment, acquisition or in-licensing opportunities.

Kill the weeds, save the flower: New treatment possibility emerges for fatal childhood brain cancer

Scientists have identified an enzyme that, when inhibited, could curtail the spread of medulloblastoma and limit the need for chemo and radiation.

Illumina lays off 5% of employees as sales forecasts falter

Illumina has begun to lay off about 5% of its global workforce spanning more than 9,100 people, a move the DNA sequencing giant described as “proactively realigning” its core operations in the face of broader macroeconomic difficulties.

NICE gives thumbs-down to 5 COVID-19 drugs including AZ's Evusheld and Merck's Lagevrio

Five key COVID-19 drugs including Merck’s antiviral Lagevrio and AstraZeneca’s Evusheld could be rejected for government funding in the U.K. In draft guidance, the drug cost watchdog the National Institute for Health and Care Excellence (NICE), recommended against government coverage because of concerns about either their cost or effectiveness. Gilead’s Veklury, Regeneron’s Ronapreve and GSK-Vir Biotechnology’s Xevudy also made their list.

HLTH22: Google, Epic ink deal to migrate hospital EHRs to the cloud to ramp up use of AI, analytics

LAS VEGAS—Google Cloud and Epic, one of the largest medical records software companies in the U.S., inked a deal to enable hospital customers to run their Epic workloads on the tech giant's cloud technology.

'The mood around here today is not great': Pear Therapeutics trims workforce by another 22%

For the second time this year, Pear Therapeutics is laying off employees to cut costs and extend its cash runway through 2023.

Yet more data underscore the growing risk of suicide among youths

Thousands of youngsters were rushed to emergency departments because of suicidal ideation. The problem, bad before the pandemic, appears to be getting worse.
 
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'The Top Line': A recap of Fierce Biotech's Cell & Gene Therapy Forum

This week on “The Top Line,” we share some highlights from Fierce Biotech's Cell and Gene Therapy Forum in case you missed it.
 

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