Plus our top stories of the week

Editor’s Note: The Fierce Life Sciences Weekly Digest will not publish next week, November 24, in observance of the U.S. Thanksgiving holiday. Thank you for reading, and we’ll be back in your inboxes December 1.

This Week

Nov 17, 2023

Pfizer's cost-cutting campaign hits Sandwich site in UK, where 500 workers will lose jobs


Novartis pays Legend $100M upfront to give solid tumor CAR-T the T-Charge treatment


Weight loss Zepbound: Eli Lilly's new obesity drug name tests well as it follows Novo's Ozempic-Wegovy branding separation


Verve shows base editing works in humans in first clinical data—and is punished by investors


AstraZeneca's long-term GLP-1 play is weight management, not obesity, CEO says


UPDATED: Novo Nordisk fights back at Lilly with Wegovy combo trial against Zepbound in obesity


Capturing COVID: Biopharma through the lens during the pandemic

 

Featured

Pfizer's cost-cutting campaign hits Sandwich site in UK, where 500 workers will lose jobs

Pfizer plans to cut approximately 500 roles and ax its Pharmaceutical Sciences Small Molecule capabilities at its site in Sandwich in Kent in the U.K. The move is a consequence of Pfizer’s enterprisewide cost realignment program, which the drugmaker unveiled in mid-October.
 

Top Stories

Novartis pays Legend $100M upfront to give solid tumor CAR-T the T-Charge treatment

Novartis is going to give a solid-tumor-focused cell therapy the T-Charge treatment after paying $100 million upfront to Legend Biotech for a selection of CAR-T candidates.

Weight loss Zepbound: Eli Lilly's new obesity drug name tests well as it follows Novo's Ozempic-Wegovy branding separation

Eli Lilly nabbed a coveted FDA approval for its obesity drug this month and, despite using the same ingredient as its diabetes drug Mounjaro, the U.S. Big Pharma has created a dividing line between the two franchises.

Germany considers banning the export of Novo Nordisk's Ozempic

How popular have Novo Nordisk’s semaglutide drugs become for weight loss in Europe? The craze is such that Germany’s drug regulator is considering banning the export of Ozempic, according to a report in Der Spiegel magazine.

AstraZeneca's long-term GLP-1 play is weight management, not obesity, CEO says

A day after AstraZeneca inked a new $185 million licensing deal to reenter the GLP-1 frenzy, CEO Pascal Soriot says the future marketplace will center less on treating obesity and more on sustained weight management. 

UPDATED: Novo Nordisk fights back at Lilly with Wegovy combo trial against Zepbound in obesity

In response to an onslaught from Eli Lilly, Novo Nordisk is escalating the obesity market battle with a new head-to-head trial against its archrival.

Novo Nordisk devotes $6B to expanding production as CEO indicates more to come

As demand continues to surge for the Ozempic-Wegovy duo of diabetes and obesity meds, Novo Nordisk is investing heavily to boost production capacity with a new trench worth more than $6 billion.

Verve shows base editing works in humans in first clinical data—and is punished by investors

Verve Therapeutics has published the first data on an in vivo base editing program in humans, giving the world an early look at the effects of a cholesterol-busting candidate that could become part of Eli Lilly’s stable of heart disease drugs. But investors pummeled the stock amid potential safety concerns.

ResMed revamps operating model with C-suite shuffle, bids farewell to COO and CTO

The C-suite makeover is aimed at emphasizing ResMed’s focus on product development, profitable growth and strengthened branding, according to a company announcement.

First live birth of a chimeric monkey is a technical feat, but pushes ethical boundaries

Researchers have reported the first-ever live birth of a chimeric monkey developed largely from embryonic stem cells. While the advancement is a technical achievement, it also raises ethical concerns.

Capturing COVID: Biopharma through the lens during the pandemic

A few months ago, Fierce Pharma asked employees working in the biopharma industry to use photographs to tell their stories during the pandemic. Now, we’re showcasing those precious memories here. 
 
Fierce podcasts

Don’t miss an episode

'Podnosis': A deep dive into Q3 earnings, and key takeaways from the Fierce Health Payer Summit

In this week’s episode of "Podnosis," you'll hear from two journalists from the Fierce Healthcare team: Paige Minemyer, senior editor of Fierce Health Payer, and Dave Muoio, a staff writer for Fierce Healthcare. Together, they guide you through their key insights from the inaugural Fierce Health Payer Summit in Austin and dive into the latest earnings updates from the largest health plans and health systems.
 

Resources

Whitepaper

Effective Technology Transfers for Mammalian-Derived Biologics

As a leader of technology transfer activities in the industry, Lonza understands the challenges associated with this critical step. Download this White Paper today to learn more. 

Whitepaper

The Drug Supply Chain Security Act & How Companies Can Prepare for Compliance

DSCSA Compliance with a Trusted Partner
Whitepaper

Powering AI Discovery with Scientific Articles

Your guide to accessing, managing, and licensing the content that fuels AI, machine learning, and data visualization projects across the enterprise.
Webinar

Reimagine the infrastructure that makes science possible

Watch now to explore the convergence of science, capital, operational excellence and workplace strategy.
Whitepaper

Overcome Challenges and Secure Successful Technology Transfers of Complex Biological Products in Sterile Manufacturing

A critical area to consider in selecting a CDMO is their ability to successfully complete technology transfers, which involves an intricate set of activities and disciplines that, if done incorrectly, could result in delays and failures that impact the overall success of your end product. Recognizing what it takes to complete this process effectively and efficiently is crucial to selecting the best partner for your project and product needs. This white paper delivers an analysis of critical success factors for effective technology transfer.
Whitepaper

Enhance the cost-effectiveness of your GMP chemical supply chain

Learn how to develop a high-performing supply chain for cGMP chemicals used throughout your bioprocessing workflows.
Whitepaper

Plasmid DNA Design Considerations for Cell and Gene Therapy

Download our whitepaper to learn about plasmid DNA design considerations for cell and gene therapy applications.
Whitepaper

Artificial Intelligence in Healthcare & Medical Affairs

This paper explores AI’s potential impact on healthcare and on Medical Affairs (MA) more specifically. It also outlines what MA teams can do now to proactively leverage AI to improve service to their stakeholders.
Whitepaper

Improving patient outcomes with point-of-care AI

Is pharma spending money on the wrong types of AI? Here’s how real-time clinical alerts could change the minds of the world’s top commercial leaders.
Whitepaper

The transformative role of pDNA in Cell and Gene therapy

Want to know the Top 5 criteria for selecting the ‘right’ CDMO for pDNA manufacturing?
eBook

Improving yield and reproducibility with advanced sample prep

Learn how to get better results from suboptimal biospecimens for NGS and protein analysis.
eBook

An Introduction to Organ-on-a-Chip Technology

Emulate in vivo biology with next-generation in vitro technology.
Whitepaper

Accelerate drug discovery with high-performance computing powered by the cloud

Accelerate drug discovery with high-performance computing (HPC) powered by the cloud
 

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