Today's Rundown SABCS: AstraZeneca, Daiichi's ADC keeps breast cancer at bay for 16 months Correvio Pharma shows heart drugs aren't always an easy sell at FDA Leo's Dupixent rival hits all endpoints in pivotal program SABCS: Seattle Genetics hails 'stunning' tucatinib breast cancer data SABCS: MacroGenics' margetuximab posts OS gains in specific metastatic breast cancer patients Sanofi to restructure its Onduo, Verily partnership alongside diabetes exit Featured Story | | | Wednesday, December 11, 2019 AstraZeneca and Daiichi Sankyo’s antibody-drug conjugate staved off cancer for a median of 16.4 months and shrank tumors in 61% of patients with HER2-positive breast cancer. The treatment could become an option for patients whose cancer worsens despite undergoing HER2-targeted therapies. |
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Top Stories Wednesday, December 11, 2019 After Novartis’ near $10 billion buyout of The Medicines Company, and with it the biotech’s leading heart drug hopeful, many thought cardiovascular therapies were hot again. Wednesday, December 11, 2019 Leo Pharma’s tralokinumab has hit all the primary and secondary endpoints in its three pivotal trials. The data position Leo to file for approval of the Dupixent rival in atopic dermatitis next year, but the lack of numbers shared publicly make it impossible to gauge whether tralokinumab is a threat to Sanofi and Regeneron’s blockbuster incumbent. Wednesday, December 11, 2019 Seattle Genetics has shared more of the tucatinib data it hopes will win it approval in HER2-positive breast cancer. The pivotal trial linked the tyrosine kinase inhibitor to reduced risk of progression and death in patients with and without brain metastases, leading Seattle Genetics CEO Clay Siegall to hail the data as “stunning.” Wednesday, December 11, 2019 MacroGenics presented new, phase 3 breast cancer data from its HER2-targeting antibody margetuximab as it works to put the finishing touches on the drug’s approval application to the FDA in the final weeks of this year. Tuesday, December 10, 2019 As its new CEO begins to move Sanofi away from new diabetes research, the drugmaker—and producer of one of the world’s top-selling insulins—will also look to pull back from its three-year-old relationship with Verily and their virtual diabetes clinic, Onduo. Resources Sponsored by: Catalent Learn how recent innovations in demand-led supply and direct-to-patient distribution are converging to create a next-generation clinical supply chain that is flexible, lean and most importantly patient-centric. 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Sponsored by: Amazon Web Services From IoT to data management to high-performance computing and machine learning, leading life sciences organizations are using Amazon Web Services (AWS) to develop scalable, global, predictable, and secure solutions to modernize clinical trials while mitigating risks Sponsored by: Outer Edge Technology, LLC See why visionaries outsource the design and management of the infrastructure allowing their scientists to innovate. Sponsored by: Veeva Systems Medical Affairs 2025 brings together leading perspectives from AstraZeneca, Bristol-Myers Squibb, Merck, Lilly, and other innovative life sciences organizations on key challenges impacting medical affairs and a roadmap for success in the coming decade. Sponsored by: IBM Watson Health IBM’s highlighted solutions reside in a security-rich cloud environment—home for capturing, managing and analyzing clinical study data with control, accuracy and confidence. These solutions lay the groundwork for further integration with IBM® Watson® cognitive technology. Sponsored by: IBM Watson Health Inpatient View and Outpatient View are powered by robust data assets and use sophisticated projection methodologies to help ensure accuracy of reporting. Sponsored by: IBM Watson Health Acknowledging various stakeholder networks, as well as recognizing variances within the regulatory environment, we believe, is essential for companies looking to uncover the right decision-makers in support of biologics or biosimilars. Learn more. Sponsored by: Eli Lilly and Company in partnership with Xcenda Download this complimentary paper that explores the practice of step therapy and its impact on key stakeholders in the US healthcare system. Sponsored by: Catalent Download the case study to learn about the clinical supply management tools that helped a small sized pharma company during phase III of a multi-arm oncology study. 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