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December 14, 2018

Welcome to FierceLifeSci Weekly Digest, your roundup of the biggest and most popular stories from each of our publications.

Featured Story

Jeans and other drugs: Novartis CEO Narasimhan's prescription for a millennial-friendly culture

What does it take for a company to attract millennials? An inspiring and empowering culture, according to Novartis CEO Vas Narasimhan, and he's starting by loosening the dress code. Yes, even at the company's Basel headquarters.

Top Stories Of The Week

AstraZeneca’s tremelimumab fails another phase 3 cancer trial

AstraZeneca’s tremelimumab has come up short in another phase 3 trial. Having failed to improve outcomes in metastatic non-small cell lung cancer, the anti-CTLA4 antibody has now missed the primary endpoint in a phase 3 advanced head and neck cancer trial.

Moderna’s cash juggernaut rolls on with record $604M IPO

Moderna’s IPO always looked like a record breaker for biotech and came in even larger than expected at $604 million, valuing the company at an eye-watering $7.9 billion.

Merck promotes oncology, vaccine executives to replace Adam Schechter in commercial rejig

Merck & Co. boasted some major success in the sales department this year, but the company’s commercial organization will still get a makeover for 2019. Adam Schechter, president of global human health, will leave on Dec. 31, triggering an executive shake-up.

Roche’s Tecentriq wins key lung cancer approval. Its prize? A showdown with formidable Merck

Merck’s Keytruda finally has some immuno-oncology competition in first-line, non-small cell lung cancer, courtesy of Roche. But even with an FDA approval in the bag, the real test for Roche might still be to come.

Regenerating insulin-producing cells with zinc could tackle the underlying cause of diabetes

The ability to regenerate insulin-producing cells in the pancreas would do the job, but that has so far proven to be an elusive target. A team of Stanford University scientists is now searching for a solution in a common nutrient: zinc.

Roche to develop new dMMR pan-cancer test for Merck’s Keytruda immunotherapy

If you can’t beat 'em, join 'em: Roche is teaming up with its immuno-oncology competitor Merck & Co. to develop a pan-cancer companion diagnostic test for its Keytruda therapy aimed at detecting the mismatch repair deficiency biomarker, or dMMR, in solid tumors regardless of their location.

Pfizer still unable to get on top of problems at Hospira injectables plant

Since Pfizer’s Kansas plant received an FDA warning letter last year, the company has insisted it is making good progress on turning things around at the essential but troubled injectables facility. But the findings from the most recent inspection show problems persist, and most of them the FDA had flagged before.

Merck’s Ebola vaccine has 'major impact,' but U.S. should help as outbreak worsens: experts

More than 40,000 people have received Merck & Co.’s Ebola vaccine in the latest outbreak—the second-largest ever—but experts are still calling on the U.S. to send back CDC specialists to help contain it.

TrialSpark debuts first clinical trial sites as part of deal with Novartis

New York-based tech CRO TrialSpark launched its first clinical trial sites as part of a partnership with Novartis that takes a new direction.

Resources

[eBook] Digital Workflows: How to Focus Investment to Cut Costs and Drive Growth

Life sciences companies must immediately identify and realize productivity gains to drive down operational costs—or risk seeing more nimble competitors disappear into the distance. Where to begin?

[Whitepaper] Evaluating RIM Suites? Unification matters.

Learn how to spot an imposter with an integrated suite vs. one that’s unified. Read this whitepaper to learn more.

[Whitepaper] In-House Versus Outsource: A Decision-Making Guide

Read this whitepaper to learn how the biologics market is quickly evolving and how these changes pose several risks to a molecule’s success.

[Whitepaper] Evaluation of the claraT Total mRNA report in an RNA- Sequencing dataset from malignant melanoma cancer patients treated with Ipilimumab

Download the whitepaper to learn more.

[Whitepaper] Putting the Researcher in the Driver’s Seat

Learn how to fast-track your research workflows!

[Report] Clinical Operations Report: Learn the Top Industrywide Priorities

Industry Research: Read the 2018 Unified Clinical Operations Report to find out how pharmas and CROs are evolving clinical trial processes.

[Webinar] QSP Approaches to Determine Best in Class Properties for Targeted Anabolic Growth Factor to Arthritic Joints

This on-demand webinar introduces a quantitative systems pharmacology (QSP) model of targeted anabolic growth factors for intra-articular injection for the treatment of diseased joints.

[Research Report] Challenges And Opportunities In Clinical Data Management

New research reveals more than 50% of clinical data management professionals surveyed, are not confident in the quality and completeness of their clinical trial data.

[Whitepaper] Migraine Treatment and Calcitonin Gene-Related Peptide Inhibitors: Real-World EHR Case Study

New Case Study – Leveraging Real-World Evidence From EHR to Assess Migraine Management

[Whitepaper] The Future of Cell & Gene Therapy

What does data tell us about the future of cell & gene therapy?

[eBook] 2018 Weekly Compendium

The Biopharma industry is moving at lightning speed and it can be a challenge to keep pace. Here at Biotech Primer we spend hours each week researching, writing, and editing original content for the Biotech Primer WEEKLY with one goal in mind: to help everyone better understand the latest science and technology driving today’s healthcare industry.