Atomic force microscopy (AFM) is one of the newer techniques available for virus research. AFM is a cantilever-based technique that utilizes a sharp tip to interrogate surfaces at resolutions well below the optical diffraction limit. Beyond imaging, AFM is also a powerful tool for nano-mechanical probing and nano-manipulation. One of the primary advantages of AFM is that it can operate on samples immersed in liquid. This empowers experiments on living cells at physiologically relevant conditions.
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