Having the ability to accurately measure autophagosome activity via LC3 translocation, as well as perform deep-dive analysis of small molecule activity by deriving dose response curves, can greatly enhance studies of cancer, neurodegeneration, and other diseases affected by autophagy. This application note describes several new optimized assay kits specifically designed for autophagy evaluation by flow cytometry.

San Diego-based 3D bioprinting company Organovo, presented new preclinical data on its 3D bioprinted human liver tissues for the treatment of inborn errors of metabolism (IEMs) at the World Advanced Therapies and Regenerative Medicine Congress in London.

Australia-based regenerative medicine and stem cell company Cynata Therapeutics Ltd., announced that the first patient has been dosed with the company's mesenchymal stem cell (MSC) therapy in a Phase 1 trial for steroid-resistant acute graft-versus-host disease (GvHD).

Metabolic measurement of humans and animal models is an important aspect of biomedicine. However, the limitations of current methods in metabolic measurement are not widely understood. This mini-review explains the methodological trade-offs involved in metabolic measurement with flow-through respirometry and specifically addresses limitations regarding temporal resolution and accuracy of metabolic measurement systems with practical solutions.

Scientists have discovered a genetic variant that enables an isolated Greek population to live long and healthy lives despite having an animal fatty diet.

Utilizing benchtop flow cytometry, new novel multicell GFP reporter assay was developed to help facilitate discrimination between induction of DNA damage, oxidative stress and protein misfolding.

Swiss scientists have created artificial viruses that can be used to target cancer. These designer viruses alert the immune system and cause it to send killer cells to help fight the tumor.

Dental researchers have found that frequent recreational use of cannabis-including marijuana, hashish, and hash oil-increases the risk of gum disease.

A team of chemists has now deciphered the structure of an amyloid that binds to zinc. Their approach, based on nuclear magnetic resonance (NMR), could also be used to reveal the structures of additional metal-bound amyloids.

Researchers in a New York cabbage patch are planning the first release on American soil of insects genetically engineered to die before they can reproduce.