Week 9 begins with major running back uncertainties tonight as the 49ers travel to Arizona to face the Cardinals in prime time. David Johnson and Chase Edmonds won't play tonight, which leaves newly-acquired Kenyan Drake, journeyman Alfred Morris and pass-catcher Zach Zenner as the Cardinals RBs in a tough matchup vs. SF. Are any of these options worth starting as desperation flex plays? Also, Tevin Coleman is expected to lead the SF backfield against a weak ARI rush defense, but will he have to share carries with Matt Breida, Raheem Mostert, or Jeff Wilson?

We take you through every Week 9 matchup, including Thursday Night Football, in our Starts & Sits, Sleepers & Busts and Start 'Em & Sit 'Em columns. Take advantage of notes about WR/CB matchups, Fantasy points against, expected production and more before you set your lineups.