Crosscultural design adaptations range from translation to localization. Researching general and contextual cultural differences helps you decide what type of design changes you should make.
We made the 10 heuristics posters easy to read and understand by iterating through multiple versions and improving each based on user-centered principles and methods.
Consistent design enhances learnability and is usually best for usability. But if the problem you're solving is sufficiently different, then inconsistency may be better.