| Dear Voornaam
This month, research teams at the Cancer Research UK Manchester Institute are moving into their new labs.
In April 2017, a fire severely damaged the institute's original home in the Paterson Building at The Christie hospital. Over the past few years, we've worked closely with The Christie and the University of Manchester to secure funds to build a new research centre that will allow researchers at the institute to do great science and translate their discoveries at scale.
Twice the size of the previous facility, the institute will now be spread across three floors and have a dedicated cancer biomarker centre. With the ambition of doubling the number of patients taking part in cancer trials in Manchester by 2030, a team of over 300 scientists and 400 clinicians and operational staff will move into the facility. And there’ll be several research groups from the University of Manchester’s Division of Cancer Sciences working on blood cancers and immunotherapy.
The institute's leadership and all its researchers have shown incredible resilience and flexibility over the last six years, and we look forward to seeing this new building become a space for their new ideas and collaboration.
Martin McGlown, our Head of Regional Media Relations, has reflected on the journey of how out of the tragedy of a fire this new global research facility has emerged.
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Funding & Research Opportunities |
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| | | Applications accepted all-year round |
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| | | Applications accepted all-year round |
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| | | Applications accepted all-year round |
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THE CANCER GRAND CHALLENGES ANNUAL PROGRESS MAGAZINE IS OUT Would you like to know more about how Cancer Grand Challenges teams are developing novel model systems to study cancer and mapping out the complex web of interactions that drive cancer?
Cancer Grand Challenges, a global funding initiative that we co-founded with the National Cancer Institute, has released Discover: a year of scientific creativity to celebrate the progress it’s making in taking on some of cancer’s toughest challenges.
Hear from key members of the community, discover the latest scientific highlights of the research teams and read more about the nine new challenges.
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 JOIN THE CHILDREN’S AND YOUNG PEOPLE’S CANCER RESEARCH CONFERENCE Registration is now open for our first children’s and young people’s cancer research conference, in London on 14 November.
We’re uniting researchers across multiple disciplines to share their research, discuss their thinking and meet peers to spark new ideas and collaborations. Expert scientists will address key topics, from harnessing immunotherapy and maximising data to developing biologically-driven clinical trials and improving patient and public involvement.
Register now to be part of the conversation to overcome some of the biggest challenges in children’s and young people’s cancer research.
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|  SILENCING GLIOBLASTOMA DRIVER MUTATIONS THROUGH DIET FOR CANCER PREVENTION Amodeo et al published a new study in Developmental Cell revealing that diet suppresses glioblastoma initiation by maintaining quiescence of mutation-bearing neural stem cells (NSCs) in a mouse model.
The researchers at the University College London Cancer Institute observed that p53 maintains NSCs quiescence by inducing fatty acid oxidation, and that p53 loss prematurely activates NSCs during gliomagenesis.
A fish-oil supplemented diet, containing omega-3 fatty acids, fully restored quiescence of p53-deficient NSCs and delayed tumour initiation.
The authors are interested in further exploring the links between cancer prevention and metabolism. |
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THE ROAD TO COMMERCIALISATION WITH RAJ MEHTA Raj Mehta is the co-founder and CEO of Adendra Therapeutics – winner of the 2022 Cancer Research Horizons’ New Startup of the Year Award. The startup is using new insights into dendritic cell biology to create next-generation immunotherapies for cancer patients.
We spoke to Raj about translation, commercialisation and how the life sciences industry has changed since he’s been working in it. Having established BliNK Therapeutics, Revitope Oncology and GammaDelta Therapeutics, Raj also has some valuable advice for researchers interested in commercialising their work and discusses where charities like ours fit into the translation landscape.
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 LAST CHANCE TO APPLY FOR OUR LEAN LAUNCH PROGRAMME Time is running out to apply for this year’s Lean Launch Programme, with applications closing on 3 May. Apply now to develop a hypothetical business model and learn how to talk about your idea to potential customers.
Gain funding for market-discovery activities and business adviser support, and connect with a wide network of entrepreneurs, investors and funders. You'll also receive weekly coaching on market validation and the opportunity to pitch to a panel of experienced industry stakeholders.
Apply now for the opportunity to join the leading online pre-accelerator and help make cancer research stronger. |
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|  GET YOUR EARLY BIRD TICKET FOR OUR RADIATION CONFERENCE The early bird registration deadline for our Radiation Research Conference, run in collaboration with the Association for Radiation Research, is fast approaching – get your ticket by 5 May to save up to £100.
Join us in Glasgow on 4–6 June to discover the latest technology and imaging systems in radiation research with RPS Service, our platinum sponsor.
RPS Service specialises in biological x-ray and gamma irradiators for medical and scientific research. |
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 INCREASE THE COMMERCIAL IMPACT OF YOUR DATASET The Cancer Research Horizons Data Innovation Awards can provide you with up to £75k funding to help you clean, annotate, curate, link or store data generated through Cancer Research UK-funded research projects.
Receive support in establishing a long-term data sharing strategy and help to make your datasets more accessible and usable by third parties, including commercial entities.
Together we’ll work towards developing a clean, well annotated dataset whose access can be easily managed by our team in conjunction with your research group. |
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|  HOW TO IMPROVE CANCER SCREENING UPTAKE IN THE LGBTQIA+ COMMUNITY Speaking on the Manchester Cancer Research Podcast, Jen Davies-Oliveira (PhD student) and Stewart O’Callaghan (Founder and Chief Executive of Live Through This) discuss screening access challenges and how to be more inclusive of the LGBTQIA+ community.
Both raise key questions on how language and administration can contribute to bias when working with patients.
Find out about Jen’s research into how alternative cervical screening could remove access barriers and Stewart’s advocacy for systematic change in cancer care. |
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| | | Online 12:00 PM 09 May 2023 |
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| | | Online 4:00 PM 05 July 2023 |
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| | | Online 4:00 PM 27 September 2023 |
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| | | London, UK 10 October 2023 |
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| | | London, UK 14 November 2023 |
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