Dear Voornaam,

Help us explore the reuse opportunities for data and samples in clinical and biological cancer research.

Our data and samples reuse special interest group is running a survey to help us understand how you’re currently using data and samples in your research and what challenges you’re encountering.

We’ll use this information to build on the support we provide to researchers so that they can maximise the use of data for patient benefit.

Cancer Grand Challenges
Team eDyNAmiC published three papers on ecDNA back-to-back in Nature

Paul Mischel, Howard Chang, Mariam Jamal-Hanjani of Cancer Grand Challenges team eDyNAmiC and their international collaborators have revealed insights into the mechanisms and therapeutic potential of extrachromosomal DNA (ecDNA).

The team analysed the genomes from nearly 15,000 patients from the Genomics England Cohort, in work co-led by collaborator Charlie Swanton, across 39 different tumour types, the largest single collection of whole-genome sequenced cancer patient samples available. They have shown the prevalence of ecDNA in samples associated with tumour stage, treatment, metastases, decreased survival and immune evasion.

Publishing three back-to-back papers in Nature and landing ecDNA on the cover, eDyNAmiC are rapidly advancing our understanding of ecDNA.

Take a deeper dive into eDyNAmiC's journey so far, going all the way from fundamental mechanisms through to identifying an actionable target that's already being tested in the clinic.

Team eDyNAmiC is funded by us and the National Cancer Institute through Cancer Grand Challenges.