This month our Centre for Drug Development (CDD) signed agreements with the biotech companies NovalGen and KisoJi to deliver clinical trials of their lead assets, which both aim to reduce toxicity without sacrificing efficacy.
NovalGen’s NVG-222 is a bispecific T-cell engager that could be used to treat both blood cancers and solid tumours. It is the first agent to use NovalGen’s AutoRegulation technology, designed to mitigate toxicity and improve the therapeutic index of T-cell engagers.
KisoJi’s KJ-103 is the first naked anti-TROP2 antibody, which, unlike ADCs, does not require a cytotoxic payload but instead recruits immune cells to kill tumour cells.
Lars Erwig, Director of the CDD, said, “We are always searching for promising new therapies that offer patients effective treatment while lowering the risks of toxicity.” |