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17 September 2021 On 16 September 2021, the Ministry of Health of Guinea declared the end of the Marburg virus disease outbreak in Guéckédou prefecture, Nzérékoré Region. In accordance with WHO recommendations, the declaration was made 42 days after the safe and dignified burial of the only confirmed patient reported in this outbreak. This was the first-ever Marburg virus disease case reported in Guinea. From 3 August 2021 to the end of outbreak declaration, only one confirmed case was reported. The patient, a man, had onset of symptoms on 25 July. On 1 August he went to a small health facility near his village, with symptoms of fever, headache, fatigue, abdominal pain and gingival hemorrhage. A rapid diagnostic test for malaria returned a negative result, and the patient received ambulatory supportive care with rehydration and symptomatic treatment. Upon returning home, his condition worsened, and he died on 2 August. An alert was subsequently raised by the sub-prefecture public health care facility to the prefectorial department of health in Guéckédou. The investigation team was immediately deployed to the village to conduct an in-depth investigation and collected a post-mortem oral swab sample, which was shipped on the same day to the viral hemorrhagic fever laboratory in Guéckédou city. On 3 August, the sample tested positive for Marburg virus disease by reverse transcriptase-polymerase chain reaction (RT-PCR) and negative for Ebola virus disease. The deceased patient was buried safely and with dignity on 4 August, with the support of the national Red Cross. On 5 August, the National Reference Laboratory in Conakry provided confirmation by real-time PCR of the positive Marburg result, and on 9 August, the Institut Pasteur Dakar in Senegal provided an additional confirmation that the result was positive for Marburg virus disease and negative for Ebola virus disease. Public health responseThe Ministry of Health activated the national and district emergency management committees to coordinate the response and engage with the community. Additionally, the Ministry of Health together with WHO, the United States Centers for Disease Control, the Alliance for International Medical Action, the Red Cross, UNICEF, the International Organization for Migration, and other partners, initiated measures to control the outbreak and prevent further spread including the implementation of contact tracing and active case search in health facilities and at the community level. During the outbreak, a total of one confirmed case who died, (CFR=100%) and 173 contacts were identified, including 14 high risk contacts based on exposure. Among them, 172 were followed for a period of 21 days, of which none developed symptoms. One high-risk contact was lost to follow up. At the different points of entry in Guéckédou prefecture where passengers were screened, no alerts were generated. Ongoing activities include:
WHO risk assessmentMarburg virus disease (MVD) is an epidemic-prone disease associated with high case fatality ratios (CFR 24-90%). In the early course of the disease, clinical diagnosis of MVD is difficult to distinguish from many other tropical febrile illnesses, because of the similarities in the clinical symptoms. Other viral hemorrhagic fevers need to be excluded, particularly Ebola virus disease (EVD), as well as malaria, typhoid fever, leptospirosis, rickettsial infection and plague. MVD is transmitted by direct contact with the blood, bodily fluids and/or tissues of infected persons or wild animals (e.g., monkeys and fruit bats). Investigations are ongoing to identify the source of the infection. Guinea has previous experience in managing viral hemorrhagic diseases such as EVD and Lassa fever, but this was the first time that MVD was reported. The country has a fragile health care system due to the overburden of disease outbreaks, COVID-19 pandemic, and the recurrent threat of epidemics such as malaria, yellow fever, measles, Lassa fever, EVD, health care-associated infections, high rates of acute malnutrition, cyclical natural disasters such as floods, and socio-political unrest. Guinea health authorities responded rapidly to the event, and measures were rapidly implemented to control the outbreak. Cross-border population movement and community mixing between Guinea and neighboring Sierra Leone and Liberia increased the risk of cross-border spread. Sierra Leone and Liberia health authorities activated contingency plans and started public health measures at the points of entry with Guinea. The affected village is in a remote forest area located at the border with Sierra Leone, about 9 km from a main international border crossing point between the two countries. The proximity of the affected area to an international border, cross-border movement between the affected district and Sierra Leone, and the potential transmission of the virus between bat colonies and humans posed an increased risk for cross-border spread. These factors suggested a high risk at the national and regional level, and given that Guéckédou prefecture is well connected to Foya in Liberia, and Kailahun in Sierra Leone, this outbreak required an immediate and coordinated response with support from international partners. The risk associated with the event at the global level was assessed as low. WHO adviceHuman-to-human transmission of Marburg virus is primarily associated with direct contact with blood and/or bodily fluids of infected persons, and Marburg virus transmission associated with the provision of health care has been reported when appropriate infection control measures have not been implemented. Health care workers caring for patients with suspected or confirmed Marburg virus disease should apply standard and transmission-based IPC precautions to avoid any exposure to blood and/or bodily fluids, as well as unprotected contact with the possibly contaminated environment. IPC precautions include:
IPC assessments of health facilities in affected areas using the IPC Scorecard revealed sub-optimal results highlighting the need for ongoing supportive supervision and mentorship for implementation of IPC in health care settings in addition to implementing IPC minimum requirements to support and strengthen future preparedness for emerging and re-emerging infectious diseases. Integrated disease surveillance and response activities, including community-based surveillance must continue to be strengthened within all affected health zones. Raising awareness of the risk factors for Marburg virus disease and the protective measures individuals can take to reduce human exposure to the virus are the key measures to reduce human infections and deaths. Key public health communication messages include:
To reduce the risk of wildlife-to-human transmissions, such as through contact with fruit bats, monkeys, and apes:
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