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Drug Solubility and the Need for Speed

A growing number of new chemical entities are highly insoluble, leading to problems with bioavailability. This playbook looks at why insolubility is an issue, the properties that affect solubility, and consider the methods used to improve solubility and bioavailability. It takes a closer look at the particular challenges associated with oncology drugs, where the proportion of insoluble drugs in development is particularly high.