The structure of individual molecules and their properties, such as chirality, are difficult to monitor in real time. It turns out that temporarily bridging molecules together can provide a lens into their dynamics. Scientists now have exposed new pathways for investigating biochemical reactions at the nanoscale. They found that optoplasmonic coupling allows for the detection of biomolecules that approach nanoparticles, while they attach, detach, and interact in a variety of ways. The technique paves the way for many future single-molecule analysis techniques that researchers have only been dreaming about.
